Gene: PTGES
Official Full Name: prostaglandin E synthaseprovided by HGNC
Gene Summary: The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03470 | PTGES Knockout cell line (HeLa) | Human | PTGES | 1:3~1:6 | Negative | Online Inquiry |
KO03471 | PTGES Knockout cell line (HCT 116) | Human | PTGES | 1:2~1:4 | Negative | Online Inquiry |
KO03472 | PTGES Knockout cell line (A549) | Human | PTGES | 1:3~1:4 | Negative | Online Inquiry |
PTGES Gene Knockout Cell Lines represent an innovative tool in genetic research, specifically designed for studies investigating the role of the PTGES gene, which encodes prostaglandin E synthase. By employing advanced CRISPR-Cas9 gene-editing technology, these engineered cell lines enable researchers to investigate the functional consequences of PTGES deletion, leading to enhanced understanding of various biological processes, including inflammation and tumorigenesis. This precise knockout mechanism eliminates the confounding variables often present in other methods, establishing a clear pathway for the exploration of gene function.
The key functionality of PTGES Gene Knockout Cell Lines lies in their ability to facilitate not only the study of gene expression alterations but also downstream effects on signaling pathways, cellular responses, and metabolic shifts. This offers a versatile platform for both basic and applied research, allowing scientists to dissect the mechanistic roles of PTGES in various contexts, from developmental biology to disease states, thus bridging the gap between fundamental research and therapeutic applications.
The scientific importance of these cell lines cannot be overstated, as they serve as a valuable asset in understanding the etiology of conditions linked to aberrant prostaglandin metabolism, such as cancers and autoimmune diseases. Furthermore, these knockout models pave the way for drug discovery efforts targeting prostaglandin signaling, making them indispensable in the pharmacological industry.
Comparatively, PTGES Gene Knockout Cell Lines offer unique advantages over alternative models, including the absence of off-target effects commonly associated with traditional gene silencing techniques, and the capability for advanced in vivo application when further validated in animal models. This specificity enhances the reliability of research outcomes, making it an essential tool for researchers seeking robust data.
For researchers and clinicians alike, investing in PTGES Gene Knockout Cell Lines means employing a state-of-the-art, scientifically validated method for elucidating gene function and pathophysiology. The unraveling of PTGES-related pathways may lead to breakthroughs in targeted therapies and personalized medicine strategies, offering significant opportunities for innovation in therapeutic approaches.
With a strong commitment to quality and scientific excellence, our company prides itself on providing premium biological products, including the PTGES Gene Knockout Cell Lines, which are engineered to meet the evolving needs of the research community. Our expertise and dedication to advancing genetic research ensure that our offerings are at the forefront of scientific progress.
Please note that all services are for research use only. Not intended for any clinical use.
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