Gene: POC1A
Official Full Name: POC1 centriolar protein Aprovided by HGNC
Gene Summary: POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome. [provided by RefSeq, Sep 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28681 | POC1A Knockout cell line (HeLa) | Human | POC1A | 1:3~1:6 | Negative | Online Inquiry |
KO28682 | POC1A Knockout cell line (HCT 116) | Human | POC1A | 1:2~1:4 | Negative | Online Inquiry |
KO28683 | POC1A Knockout cell line (HEK293) | Human | POC1A | 1:3~1:6 | Negative | Online Inquiry |
KO28684 | POC1A Knockout cell line (A549) | Human | POC1A | 1:3~1:4 | Negative | Online Inquiry |
POC1A Gene Knockout Cell Lines are meticulously engineered cellular models designed to explore the role of the POC1A gene in various biological processes. These cell lines have been generated through CRISPR-Cas9 technology to create targeted disruptions in the POC1A gene, which is known to be involved in centrosome function and cell division. By studying these knockout lines, researchers can elucidate the implications of POC1A deficiency on cellular architecture, mitotic fidelity, and even oncogenesis.
The key function of the POC1A Gene Knockout Cell Lines is to provide an essential tool for dissecting the contributions of POC1A in cellular pathways and interactions. This product allows for the observation of resultant phenotypes in cell cycle progression and can assist in identifying potential therapeutic targets for diseases associated with centrosome dysfunction, including various cancers and developmental disorders. By utilizing these cell lines, scientists can perform high-throughput screening experiments, pathway analyses, and cellular rescue studies, ultimately advancing our understanding of molecular mechanisms underpinning disease.
The scientific importance of the POC1A Gene Knockout Cell Lines is underscored by their versatile applications in both research and clinical settings. These cell lines are indispensable tools for drug discovery efforts, particularly in identifying compounds that target pathways affected by POC1A deficiency. Furthermore, they can aid in the development of gene therapies aimed at restoring normal function.
Compared to alternative models, the unique selling points of POC1A Gene Knockout Cell Lines lie in their precision and reliability. While conventional gene knockdown approaches, such as RNA interference, often yield transient effects, CRISPR-Cas9-generated knockout lines offer a stable, long-term gene modification, providing more consistent experimental conditions and enabling reproducibility in scientific studies.
For researchers and clinicians seeking novel insights into gene function, cell signaling, and potential disease mechanisms, POC1A Gene Knockout Cell Lines represent a significant advancement in biological research tools. By employing this product, users are empowered with a powerful method to not only investigate fundamental biological questions but also to propel the development of innovative therapeutic strategies.
Our company specializes in producing high-quality, genetically modified cell lines, leveraging cutting-edge technologies to ensure precision and reliability in every product. We pride ourselves on facilitating groundbreaking research by providing exceptional cellular tools that meet the needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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