Gene: PLXNA2
Official Full Name: plexin A2provided by HGNC
Gene Summary: This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36022 | PLXNA2 Knockout cell line (HeLa) | Human | PLXNA2 | 1:3~1:6 | Negative | Online Inquiry |
KO36023 | PLXNA2 Knockout cell line (HEK293) | Human | PLXNA2 | 1:3~1:6 | Negative | Online Inquiry |
PLXNA2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the plexin A2 gene, a key player in neuronal signaling and cellular migration. These knockout cell lines provide a powerful tool for researchers investigating the intricate roles of PLXNA2 in various biological processes, including neurodevelopment, axon guidance, and the progression of neurological disorders.
The primary function of these cell lines revolves around their ability to mimic the effects of PLXNA2 deficiency, allowing scientists to study downstream signaling pathways and cellular responses without the confounding influence of the gene's expression. By employing techniques such as CRISPR-Cas9 gene editing, these cell lines exhibit a complete knockout of the target gene, facilitating investigations into the molecular mechanisms that contribute to neurological diseases such as Alzheimer's and schizophrenia.
The scientific importance of PLXNA2 Gene Knockout Cell Lines extends to their applications in drug discovery and developmental biology. Researchers can utilize these models to screen for novel therapeutic compounds, assess their efficacy, and better understand the effects of PLXNA2 modulation on neuronal function. Furthermore, these cell lines are invaluable in elucidating the role of plexin receptors in cell behavior, providing insights that can lead to breakthroughs in treating complex disorders.
What sets our PLXNA2 Gene Knockout Cell Lines apart from traditional cell models is the assurance of a complete and stable knockout, along with comprehensive characterization data. While alternative models often suffer from variable gene expression or incomplete knockouts, our product is optimized for reproducibility and reliability, ensuring that researchers can draw meaningful and consistent results from their experiments.
Investing in PLXNA2 Gene Knockout Cell Lines equips researchers and clinicians with robust tools for advancing our understanding of critical biological pathways, enhancing the potential for innovative therapeutic strategies. Our company's commitment to providing high-quality biological products underscores our expertise in developing tailored cell lines that meet the evolving needs of the scientific community. With our PLXNA2 Gene Knockout Cell Lines, you can achieve unprecedented insights into the role of plexin A2 in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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