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PI15 Knockout Cell Lines

Gene: PI15

Official Full Name: peptidase inhibitor 15provided by HGNC

Gene Summary: This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23149 PI15 Knockout cell line (HCT 116) Human PI15 1:2~1:4 Negative Online Inquiry

Background

PI15 Gene Knockout Cell Lines are specifically engineered cellular models that have been genetically modified to lack the expression of the PI15 gene, providing a crucial tool for elucidating the biological functions of this gene in various physiological and pathological contexts. The PI15 gene has been implicated in critical processes such as cellular growth, apoptosis, and immune responses, making these knockout cell lines invaluable for detailed studies of gene function and regulation.

These cell lines operate through a precise mechanism of gene editing that typically employs CRISPR-Cas9 technology, allowing for the removal or disruption of the PI15 gene with high specificity. This targeted approach creates a robust system for researchers to dissect the role of PI15 by comparing knockout phenotypes with wild-type controls. Researchers can investigate alterations in cell signaling pathways, gene expression profiles, and phenotypic behaviors, thereby generating insights into the gene's involvement in diseases such as cancer and autoimmune disorders.

The scientific importance of PI15 Gene Knockout Cell Lines extends beyond basic research; they hold significant potential in preclinical drug development and therapeutic interventions. By providing a model that mimics certain disease states or cellular dysfunctions, these cell lines facilitate high-throughput screening and validation of novel compounds aimed at restoring normal cellular function.

One of the primary advantages of our PI15 Gene Knockout Cell Lines lies in their reproducibility and reliability. Compared to alternative products such as transient knockdown systems, which can yield inconsistent results due to variable expression levels, our knockout lines offer stable gene loss that provides a consistent platform for experimentation. Moreover, they can be used in a variety of assay formats, further enhancing their utility in diverse research settings.

By offering PI15 Gene Knockout Cell Lines, we are empowering researchers and clinicians to advance their studies with cutting-edge tools that promote deeper biological insights and accelerate therapeutic breakthroughs. Our commitment to quality and innovation in biological products stems from years of expertise in the field, assuring users of the highest standards in experimental support and performance.

Please note that all services are for research use only. Not intended for any clinical use.

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