Home / PER3 Knockout Cell Lines

PER3 Knockout Cell Lines

Gene: PER3

Official Full Name: period circadian regulator 3provided by HGNC

Gene Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33770 PER3 Knockout cell line (HeLa) Human PER3 1:3~1:6 Negative Online Inquiry
KO33771 PER3 Knockout cell line (HCT 116) Human PER3 1:2~1:4 Negative Online Inquiry
KO33772 PER3 Knockout cell line (HEK293) Human PER3 1:3~1:6 Negative Online Inquiry
KO33773 PER3 Knockout cell line (A549) Human PER3 1:3~1:4 Negative Online Inquiry

Background

PER3 Gene Knockout Cell Lines represent a cutting-edge biological product designed for the in-depth study of circadian rhythms and their role in various physiological processes. These cell lines have been genetically engineered to lack the PER3 gene, a critical component of the core circadian clock machinery. By disabling this gene, researchers can investigate the resultant effects on cellular processes such as metabolism, cell division, and stress responses, thereby elucidating the role of circadian rhythms in health and disease.

The key function of PER3 Gene Knockout Cell Lines lies in their ability to mimic the altered physiological states often observed in certain disorders, such as sleep disorders, metabolic syndromes, and mood disorders. The absence of the PER3 gene disrupts normal circadian signaling pathways, allowing for detailed analysis of how these disruptions contribute to various pathologies. This model system enables researchers to explore mechanisms at the molecular, cellular, and system levels, providing vital insights into how circadian regulation impacts cellular function.

The scientific importance of these cell lines is manifold; they support applications ranging from basic research in chronobiology to translational studies aimed at developing therapeutic interventions for circadian-related conditions. The PER3 knockout model is invaluable for studies exploring the interplay between genetics and environment in circadian biology, enhancing our understanding of biological rhythms in both health and disease contexts.

One of the unique advantages of the PER3 Gene Knockout Cell Lines is their specificity and reliability in modeling circadian disruptions compared to standard cell lines that may not accurately reflect these processes. Moreover, these lines are generated using advanced CRISPR/Cas9 technology, ensuring high precision and reproducibility. This specificity offers researchers a powerful tool to validate hypotheses and screen for potential therapeutic compounds that may target circadian-related pathways.

In conclusion, the value of the PER3 Gene Knockout Cell Lines to researchers and clinicians lies in their potential to reveal critical insights into circadian biology, enabling strategic advancements in therapeutic strategies. Developed by our expert team dedicated to providing high-quality biological products, these cell lines reflect our commitment to enhancing research and innovation in the life sciences field.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.