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PDCD6 Knockout Cell Lines

Gene: PDCD6

Official Full Name: programmed cell death 6provided by HGNC

Gene Summary: This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32385 PDCD6 Knockout cell line (HeLa) Human PDCD6 1:3~1:6 Negative Online Inquiry
KO32386 PDCD6 Knockout cell line (HCT 116) Human PDCD6 1:2~1:4 Negative Online Inquiry
KO32387 PDCD6 Knockout cell line (HEK293) Human PDCD6 1:3~1:6 Negative Online Inquiry
KO32388 PDCD6 Knockout cell line (A549) Human PDCD6 1:3~1:4 Negative Online Inquiry

Background

PDCD6 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted modification to disrupt the PDCD6 gene, which is integral to various cellular processes such as apoptosis and calcium signaling. These knockout cell lines serve as vital tools for researchers aiming to explore the numerous biological roles of PDCD6, including its involvement in programmed cell death and immune response modulation. By creating a model where the PDCD6 gene is inactivated, researchers can better understand the underlying mechanisms that govern cell survival and death, facilitating the investigation of various pathological conditions including cancer, autoimmune diseases, and neurodegenerative disorders.

The key mechanism of action of PDCD6 knockout involves the deregulation of the signaling pathways that are dependent on calcium ions, which can lead to altered responses in apoptosis and cell proliferation. By utilizing these cell lines, scientists can elucidate the consequences of PDCD6 absence, contributing valuable insights into how this gene affects cellular behavior under physiological and pathological conditions.

The scientific importance of PDCD6 Gene Knockout Cell Lines is underscored in both research and clinical settings. They serve as models for drug discovery, allowing for the testing of therapeutic agents that target apoptosis pathways, and can aid in the development of gene therapy strategies. Furthermore, these cell lines are instrumental in elucidating disease mechanisms, thereby informing clinical decisions in personalized medicine.

Compared to alternatives, PDCD6 knockout cell lines offer a precise, reproducible means of studying the specific effects of gene knockout, enabling more targeted research than traditional methods such as pharmacological inhibition or siRNA approaches. Additionally, the ability to readily generate stable cell lines provides a consistent platform for long-term studies.

For researchers and clinicians seeking to deepen their understanding of cellular apoptosis and its implications in health and disease, PDCD6 Gene Knockout Cell Lines represent an invaluable resource. Our company specializes in providing high-quality genetic tools tailored for cutting-edge biological research, leveraging years of expertise to ensure that researchers have access to reliable, robust models for their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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