Home / P2RY6 Knockout Cell Lines

P2RY6 Knockout Cell Lines

Gene: P2RY6

Official Full Name: pyrimidinergic receptor P2Y6provided by HGNC

Gene Summary: The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36245 P2RY6 Knockout cell line (HeLa) Human P2RY6 1:3~1:6 Negative Online Inquiry
KO36246 P2RY6 Knockout cell line (A549) Human P2RY6 1:3~1:4 Negative Online Inquiry

Background

P2RY6 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to eliminate the expression of the P2RY6 gene, which encodes the P2Y6 receptor, a member of the purinergic receptor family. These cell lines serve as crucial tools for investigating the roles of P2Y6 in various physiological and pathological processes, including immune responses, cellular signaling, and neurobiology. By utilizing CRISPR-Cas9 technology or similar gene editing techniques, these knockout cell lines allow researchers to explore the functional implications of the receptor's absence, providing insights into its contribution to cellular communication and the underlying mechanisms of disease.

The primary function of P2RY6 involves the binding of nucleotides, such as UDP, which can activate intracellular signaling pathways crucial for cellular responses. By using P2RY6 knockout cell lines, scientists can dissect the receptor's role in various signaling cascades, ultimately leading to a better understanding of its involvement in conditions such as inflammation, cancer, and neurodegenerative diseases. This research is vital in developing targeted therapies and understanding the complex interactions within cellular environments.

The significance of P2RY6 Gene Knockout Cell Lines in scientific research and clinical applications cannot be overstated. They provide a unique platform for drug discovery and development, particularly in identifying receptor antagonists or agonists that could modulate P2Y6 activity for therapeutic benefits. Furthermore, these cell lines enable researchers to create in vitro models that closely mimic physiological conditions, essential for accurate investigations of receptor function.

One of the standout advantages of our P2RY6 Gene Knockout Cell Lines is the precision achieved in gene editing, which surpasses traditional methods that may not completely abrogate gene function. This specificity reduces off-target effects, ensuring a more reliable and reproducible research outcome. Additionally, our knockout cell lines are fully validated, providing researchers with confidence in the integrity and performance of the model.

For researchers and clinicians aiming to elucidate the P2Y6 receptor’s role in health and disease, our P2RY6 Gene Knockout Cell Lines serve as an invaluable asset in the toolkit of modern biomedical research. Our company prides itself on delivering high-quality biological products, backed by extensive experience in gene editing and cellular biology. With a commitment to supporting advancements in scientific understanding, we ensure that our products meet the highest standards of performance and reliability, empowering scientists to drive innovation in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.