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OPLAH Knockout Cell Lines

Gene: OPLAH

Official Full Name: 5-oxoprolinase, ATP-hydrolysingprovided by HGNC

Gene Summary: The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27983 OPLAH Knockout cell line (HeLa) Human OPLAH 1:3~1:6 Negative Online Inquiry
KO27984 OPLAH Knockout cell line (HCT 116) Human OPLAH 1:2~1:4 Negative Online Inquiry
KO27985 OPLAH Knockout cell line (A549) Human OPLAH 1:3~1:4 Negative Online Inquiry

Background

OPLAH Gene Knockout Cell Lines are specialized cellular models engineered to facilitate the study of gene function and associated biological processes. These cell lines have been meticulously developed using CRISPR-Cas9 technology, which allows for the precise and targeted disruption of the OPLAH gene, providing researchers with powerful tools for exploring the gene's role in metabolism, cell signaling, and disease mechanisms.

The key mechanism behind these knockout cell lines lies in the ability to create a complete loss-of-function model for the OPLAH gene. This is achieved by introducing double-strand breaks in the DNA at specific sites, leading to insertions or deletions during the natural repair process that ultimately results in a non-functional gene. This disruption facilitates detailed analyses of the OPLAH gene's contributions to various phenotypic outcomes, enabling researchers to delve into metabolic pathways and assess therapeutic potential in clinical settings.

The scientific importance of OPLAH Gene Knockout Cell Lines is substantial, as they are pivotal for investigations into metabolic disorders, neurodegenerative diseases, and various cancers, enhancing our understanding of pathophysiological conditions. Their application ranges from basic biological research to drug discovery and therapeutic development, offering insights that can lead to novel treatment strategies.

One of the unique selling points of OPLAH Gene Knockout Cell Lines is their robust validation and specificity, setting them apart from alternative models that may exhibit off-target effects or lack uniform expression. Furthermore, the availability of a user-friendly platform and extensive technical support ensures that researchers can seamlessly integrate these cell lines into their workflows, significantly accelerating their developmental timelines.

For researchers and clinicians focused on understanding genetic contributions to diseases and developing targeted therapies, OPLAH Gene Knockout Cell Lines provide a reliable and advanced resource. The value of these cell lines is amplified by our company’s reputation for excellence in producing high-quality biological products, backed by years of experience in genetic research and cellular engineering.

Please note that all services are for research use only. Not intended for any clinical use.

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