Gene: NUDT9
Official Full Name: nudix hydrolase 9provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21969 | NUDT9 Knockout cell line (HeLa) | Human | NUDT9 | 1:3~1:6 | Negative | Online Inquiry |
KO21970 | NUDT9 Knockout cell line (HCT 116) | Human | NUDT9 | 1:2~1:4 | Negative | Online Inquiry |
KO21971 | NUDT9 Knockout cell line (HEK293) | Human | NUDT9 | 1:3~1:6 | Negative | Online Inquiry |
KO21972 | NUDT9 Knockout cell line (A549) | Human | NUDT9 | 1:3~1:4 | Negative | Online Inquiry |
NUDT9 Gene Knockout Cell Lines are genetically engineered cellular models designed to investigate the biological functions of the NUDT9 gene, known for its role in regulating nucleotide metabolism and maintaining cellular homeostasis. These knockout cell lines have been meticulously developed to ensure the complete deletion of the NUDT9 gene, thereby enabling researchers to study the consequences of its absence on cellular physiology, signaling pathways, and overall cell viability.
The primary mechanism of action for these cell lines revolves around the disruption of NUDT9's enzymatic activity, which is crucial for hydrolyzing nucleoside diphosphates and preventing the accumulation of toxic nucleotides. By providing a controlled environment to observe the effects of NUDT9 deficiency, these cell lines are invaluable for understanding metabolic disorders and exploring therapeutic approaches for conditions linked to nucleotide imbalances.
In terms of scientific importance, NUDT9 Gene Knockout Cell Lines serve as essential tools in both basic and applied research scenarios, including pharmacology, toxicology, and cancer biology. Their use can facilitate the development of novel drugs targeting nucleotide metabolism or offer insights into the molecular mechanisms underpinning various diseases. Furthermore, these cell lines are pivotal for validating gene function in clinical settings, potentially guiding personalized medicine strategies.
What sets NUDT9 Gene Knockout Cell Lines apart from alternative models is their precise genetic modification and the resulting ability to consistently reproduce NUDT9-deficient conditions. This specificity allows researchers to obtain reliable and reproducible data, further enhancing the validity of their findings. Additionally, the cell lines can be adapted for high-throughput screening, providing a practical advantage for those engaged in extensive compound testing.
The value of NUDT9 Gene Knockout Cell Lines to researchers and clinicians lies in their capability to bridge basic research and clinical applications, facilitating the understanding of gene functions and interactions within cellular networks. As researchers look to uncover the complexities of nucleotide metabolism and its implications in human health, these cell lines stand out as critical resources.
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Please note that all services are for research use only. Not intended for any clinical use.
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