Gene: NUDT12
Official Full Name: nudix hydrolase 12provided by HGNC
Gene Summary: Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25446 | NUDT12 Knockout cell line (HeLa) | Human | NUDT12 | 1:3~1:6 | Negative | Online Inquiry |
KO25447 | NUDT12 Knockout cell line (HCT 116) | Human | NUDT12 | 1:2~1:4 | Negative | Online Inquiry |
KO25448 | NUDT12 Knockout cell line (HEK293) | Human | NUDT12 | 1:3~1:6 | Negative | Online Inquiry |
KO25449 | NUDT12 Knockout cell line (A549) | Human | NUDT12 | 1:3~1:4 | Negative | Online Inquiry |
NUDT12 Gene Knockout Cell Lines are specialized cellular models where the NUDT12 gene has been precisely disrupted, rendering the cells devoid of NUDT12 function. This genetic alteration facilitates the study of the specific roles and pathways influenced by the NUDT12 gene, which is known to play a pivotal role in nucleotide metabolism and cellular stress response mechanisms.
The primary function of these knockout cell lines is to provide researchers with a tool to investigate the impact of NUDT12 absence on cellular processes such as DNA repair, cell proliferation, and apoptosis. By utilizing CRISPR/Cas9 technology for gene editing, the NUDT12 Gene Knockout Cell Lines allow for the effective analysis of phenotypic changes and the elucidation of molecular pathways, making them indispensable in genetic, biochemical, and pharmacological studies.
Scientifically, the significance of NUDT12 extends to its involvement in various diseases, including cancer and neurodegenerative disorders. Its manipulation through knockout models supports the development of targeted therapies and enhances our understanding of metabolic dysregulation in different health conditions. Consequently, these cell lines are an asset in both fundamental research and preclinical studies, allowing for more personalized approaches in drug discovery and testing.
Compared to alternative models, such as wild-type or overexpression systems, NUDT12 Gene Knockout Cell Lines provide a controlled environment to precisely analyze the effects of gene loss, eliminating variables that may confound results. Moreover, their reproducibility and consistency make them highly reliable for longitudinal studies.
For researchers and clinicians, the value of NUDT12 Gene Knockout Cell Lines lies in their ability to reveal insights into gene function, aid in the identification of novel therapeutic targets, and provide a basis for advancing personalized medicine.
With extensive expertise in genetic engineering and cell line development, our company is committed to delivering high-quality tools that empower scientific discoveries, ensuring that researchers and clinicians alike have access to cutting-edge biological products to advance their work.
Please note that all services are for research use only. Not intended for any clinical use.
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