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NCOA4 Knockout Cell Lines

Gene: NCOA4

Official Full Name: nuclear receptor coactivator 4provided by HGNC

Gene Summary: This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00396 NCOA4 gRNA2 KO plasmid NCOA4 $850
KO00791 NCOA4 Knockout cell line(BEAS-2B) Human NCOA4 1:3~1:4 Negative Online Inquiry
KO09714 NCOA4 Knockout cell line (HeLa) Human NCOA4 1:3~1:6 Negative Online Inquiry
KO09715 NCOA4 Knockout cell line (HCT 116) Human NCOA4 1:2~1:4 Negative Online Inquiry
KO09716 NCOA4 Knockout cell line (HEK293) Human NCOA4 1:3~1:6 Negative Online Inquiry

Background

NCOA4 Gene Knockout Cell Lines are genetically engineered cell lines in which the NCOA4 gene has been systematically disrupted, providing a robust model for studying the biological implications of NCOA4 deficiency across various cellular contexts. The primary function of NCOA4, a coactivator of nuclear hormone receptors, is to facilitate the transcriptional regulation of target genes involved in critical cellular processes, such as metabolism, differentiation, and response to stimuli. By knocking out this gene, researchers can investigate the resultant phenotypic changes, offering insights into the gene’s role in pathophysiological conditions such as cancer, metabolic disorders, and neurodegenerative diseases.

The scientific importance of NCOA4 Gene Knockout Cell Lines extends into both research and clinical settings. These cell lines serve as invaluable tools for elucidating signaling pathways, drug discovery, and biomarker identification linked to NCOA4 functions. Furthermore, they can be applied in functional genomics studies aimed at deciphering the gene's interactions with other molecular players in health and disease.

One of the specific advantages of our NCOA4 Gene Knockout Cell Lines is the precision of gene editing employed, which ensures complete knockout without off-target effects commonly seen in alternative methods. This specificity enhances reproducibility and reliability in experimental design, a critical need in scientific research.

Researchers and clinicians will find these cell lines indispensable in advancing their understanding of genetic and molecular underpinnings of disease. Our expert team is committed to the development and distribution of high-quality biological products, ensuring that our customers have access to the latest innovations that propel research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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