Home / MTHFD2L Knockout Cell Lines

MTHFD2L Knockout Cell Lines

Gene: MTHFD2L

Official Full Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 likeprovided by HGNC

Gene Summary: Predicted to enable methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20952 MTHFD2L Knockout cell line (HeLa) Human MTHFD2L 1:3~1:6 Negative Online Inquiry
KO20953 MTHFD2L Knockout cell line (HCT 116) Human MTHFD2L 1:2~1:4 Negative Online Inquiry
KO20954 MTHFD2L Knockout cell line (HEK293) Human MTHFD2L 1:3~1:6 Negative Online Inquiry
KO20955 MTHFD2L Knockout cell line (A549) Human MTHFD2L 1:3~1:4 Negative Online Inquiry

Background

MTHFD2L Gene Knockout Cell Lines represent a significant advancement in the field of molecular biology, specifically in genetic research and therapeutic development. These cell lines have been genetically engineered to disrupt the MTHFD2L gene, which encodes for an enzyme involved in folate metabolism and one-carbon metabolism pathways. By removing this gene's function, researchers can study the resultant phenotypic changes and unravel the complex biological roles that MTHFD2L plays in cellular processes.

The primary function of MTHFD2L is to facilitate the conversion of formyl-THF to methylene-THF, participating in the synthesis of nucleotides and amino acids crucial for cell proliferation and survival. By utilizing MTHFD2L knockout cell lines, scientists can investigate the implications of folate metabolism disruption, providing insights into various pathological conditions such as cancer, developmental disorders, and metabolic syndromes. The ability to systematically explore these mechanisms emphasizes the importance of this product for research and clinical applications, particularly in developing targeted therapies aimed at metabolic pathways.

What sets MTHFD2L Gene Knockout Cell Lines apart from other genetic models is their specificity and the ability to validate hypotheses concerning MTHFD2L's role in health and disease without the confounding effects of the native gene. Compared to alternative models, these knockout lines provide a unique platform for high-throughput screening of pharmacological agents, unraveling gene function in a controlled manner.

For researchers and clinicians aiming to pioneer advancements in metabolic research or therapeutic strategies, MTHFD2L Gene Knockout Cell Lines are invaluable tools. They enable deeper insights and foster innovative approaches to address unmet clinical needs. Our company specializes in high-quality biological products, and our expertise ensures that each knockout cell line is rigorously validated and characterized, providing reliable resources for the scientific community. By choosing our MTHFD2L Gene Knockout Cell Lines, you are investing in a product designed to enhance your research capabilities and expand the frontiers of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.