Gene: MRPL54
Official Full Name: mitochondrial ribosomal protein L54provided by HGNC
Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30502 | MRPL54 Knockout cell line (HeLa) | Human | MRPL54 | 1:3~1:6 | Negative | Online Inquiry |
KO30503 | MRPL54 Knockout cell line (HCT 116) | Human | MRPL54 | 1:2~1:4 | Negative | Online Inquiry |
KO30504 | MRPL54 Knockout cell line (HEK293) | Human | MRPL54 | 1:3~1:6 | Negative | Online Inquiry |
MRPL54 Gene Knockout Cell Lines are genetically engineered cellular systems specifically designed to study the role of the MRPL54 gene, which encodes a mitochondrial ribosomal protein involved in mitochondrial translation and function. These knockout cell lines are invaluable tools for elucidating the biological pathways influenced by MRPL54, as they enable researchers to observe the effects of the gene's absence on cellular behavior, mitochondrial health, and metabolism.
The primary mechanism of these knockout lines involves targeted gene editing techniques, such as CRISPR-Cas9, to disrupt the MRPL54 gene, leading to a complete loss of function. This disruption allows scientists to analyze cellular adaptations, compensatory mechanisms, and the overall impact on mitochondrial dynamics and bioenergetics. By serving as a functional model, MRPL54 knockout cell lines facilitate insights into diseases related to mitochondrial dysfunction, including various metabolic disorders and age-related conditions.
In the research and clinical settings, the importance of MRPL54 Gene Knockout Cell Lines cannot be overstated. They provide a controlled environment for high-throughput screening of potential therapeutic agents, identification of biomarkers, and the modeling of disease states. With the growing emphasis on personalized medicine, understanding the precise roles of mitochondrial proteins like MRPL54 may lead to novel treatment strategies tailored to individual genetic profiles.
What sets our MRPL54 Gene Knockout Cell Lines apart from alternatives is their rigorous validation and consistency in performance across experiments. Each line is thoroughly characterized, ensuring that researchers can trust the integrity of their findings. Furthermore, our product is accompanied by comprehensive support and resources, enabling users to design effective experiments with ease.
For researchers, clinicians, and pharmaceutical developers alike, these knockout cell lines represent a critical asset in the exploration of mitochondrial biology. By investing in our MRPL54 Gene Knockout Cell Lines, users are leveraging advanced biotechnology to uncover insights that may propel scientific discoveries and therapeutic innovations.
Our company prides itself on a robust background in genetic engineering and cell line development, ensuring that our products are built on a foundation of scientific excellence. We are committed to supporting the scientific community by providing cutting-edge tools that cater to the evolving needs of research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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