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MPHOSPH8 Knockout Cell Lines

Gene: MPHOSPH8

Official Full Name: M-phase phosphoprotein 8provided by HGNC

Gene Summary: Enables chromatin binding activity; histone reader activity; and methylated histone binding activity. Involved in negative regulation of gene expression via chromosomal CpG island methylation and transposable element silencing by heterochromatin formation. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16084 MPHOSPH8 Knockout cell line (HeLa) Human MPHOSPH8 1:3~1:6 Negative Online Inquiry
KO16085 MPHOSPH8 Knockout cell line (HCT 116) Human MPHOSPH8 1:2~1:4 Negative Online Inquiry
KO16086 MPHOSPH8 Knockout cell line (HEK293) Human MPHOSPH8 1:3~1:6 Negative Online Inquiry
KO16087 MPHOSPH8 Knockout cell line (A549) Human MPHOSPH8 1:3~1:4 Negative Online Inquiry

Background

MPHOSPH8 Gene Knockout Cell Lines are specifically engineered cellular models that allow researchers to study the functional role of the MPHOSPH8 gene in various biological processes. By utilizing sophisticated CRISPR-Cas9 gene editing technology, these cell lines have been developed to lack the functional expression of the MPHOSPH8 gene, providing a powerful tool to investigate its contributions to cellular mechanisms such as ribosome biogenesis, protein synthesis, and overall cellular homeostasis.

These cell lines serve as vital resources for understanding the gene’s impact on cancer biology, as well as its role in pathologies linked to mitochondrial dysfunction. By comparing the knockout models to wild-type controls, researchers can elucidate the downstream effects of MPHOSPH8 loss, particularly in how it might affect cell proliferation, metabolic pathways, and resistance to various therapies.

The scientific importance of MPHOSPH8 Gene Knockout Cell Lines lies in their applications in both basic and translational research. They are instrumental for drug discovery efforts, enabling clinicians and scientists to identify potential therapeutic targets and evaluate drug responses in a controlled environment. This granularity in research can lead to breakthroughs in understanding cancer progression and enhancing treatment regimens.

What sets MPHOSPH8 Gene Knockout Cell Lines apart from alternative models is the precision of our gene editing approach and the quality control measures taken throughout the development process. Each cell line undergoes rigorous validation to ensure that gene disruption is confirmed, and phenotypic traits are consistent with expected outcomes. Additionally, these cell lines are available in various backgrounds, facilitating their use in a wide range of experimental setups.

For researchers and clinicians, the value of the MPHOSPH8 Gene Knockout Cell Lines lies in their ability to provide reliable and reproducible results that advance understanding of gene function in health and disease. Our expertise in genetic engineering and commitment to delivering high-quality biological products ensure that you have the best tools at your disposal for pioneering research. By choosing our products, you benefit from a collaborative partnership aimed at driving forward scientific discovery and improving clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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