Gene: MCUB
Official Full Name: mitochondrial calcium uniporter dominant negative subunit betaprovided by HGNC
Gene Summary: Enables calcium channel inhibitor activity. Involved in negative regulation of calcium import into the mitochondrion. Located in mitochondrial inner membrane and nucleoplasm. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16281 | MCUB Knockout cell line (HeLa) | Human | MCUB | 1:3~1:6 | Negative | Online Inquiry |
KO16282 | MCUB Knockout cell line (HCT 116) | Human | MCUB | 1:2~1:4 | Negative | Online Inquiry |
KO16283 | MCUB Knockout cell line (HEK293) | Human | MCUB | 1:3~1:6 | Negative | Online Inquiry |
KO16284 | MCUB Knockout cell line (A549) | Human | MCUB | 1:3~1:4 | Negative | Online Inquiry |
MCUB Gene Knockout Cell Lines are specialized cellular models engineered to selectively disrupt the MCUB gene, which encodes for the mitochondrial calcium uptake protein involved in cellular calcium homeostasis and energy metabolism. These cell lines utilize CRISPR-Cas9 gene editing technology to achieve precise gene knockout, enabling researchers to study the physiological and pathological roles of MCUB in various biological processes.
The key function of MCUB Gene Knockout Cell Lines lies in their ability to facilitate the investigation of mitochondrial function, calcium signaling, and their relationships to disease states such as cancer, neurodegenerative disorders, and metabolic syndromes. By removing the expression of the MCUB gene, these cell lines allow researchers to pinpoint how alterations in calcium metabolism can affect cell proliferation, apoptosis, and overall cellular health. This model is instrumental in elucidating the molecular mechanisms underlying disease and in identifying potential therapeutic targets.
From a scientific perspective, the importance of these cell lines cannot be overstated. They provide researchers with the tools necessary to investigate gene function in a controlled environment, unraveling the complexities of mitochondrial dynamics and calcium signaling. In clinical settings, these cell lines may facilitate drug discovery efforts, leading to breakthroughs in treatment strategies for conditions associated with dysregulated calcium levels.
What sets MCUB Gene Knockout Cell Lines apart from alternatives is their specificity and reliability. Unlike traditional knockout methods, CRISPR-Cas9 ensures minimal off-target effects, resulting in highly characterized cell lines that are reproducible in subsequent experiments. Researchers can trust that the findings derived from these models are both valid and translatable to in vivo systems.
The value of MCUB Gene Knockout Cell Lines is profound, as they empower researchers and clinicians alike to explore fundamental questions in cellular biology and drug development. With rigorous validation and a commitment to quality, we ensure that these products meet the highest standards for scientific research.
At our company, we pride ourselves on our expertise in creating advanced biological products tailored to address critical challenges in research. Our portfolio is built on innovation and excellence, ensuring that you have the best tools available for your scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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