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MAPKAPK2 Knockout Cell Lines

Gene: MAPKAPK2

Official Full Name: MAPK activated protein kinase 2provided by HGNC

Gene Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10627 MAPKAPK2 Knockout cell line (HeLa) Human MAPKAPK2 1:3~1:6 Negative Online Inquiry
KO10628 MAPKAPK2 Knockout cell line (HCT 116) Human MAPKAPK2 1:2~1:4 Negative Online Inquiry
KO10629 MAPKAPK2 Knockout cell line (HEK293) Human MAPKAPK2 1:3~1:6 Negative Online Inquiry
KO10630 MAPKAPK2 Knockout cell line (A549) Human MAPKAPK2 1:3~1:4 Negative Online Inquiry

Background

MAPKAPK2 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the expression of the MAPKAPK2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) gene. This gene plays a pivotal role in various intracellular signaling pathways, particularly those involved in cellular responses to stress, inflammation, and growth factor signaling. The deletion of the MAPKAPK2 gene allows researchers to study its specific functions and contributions to vital biological processes, elucidating its role in diseases such as cancer, neurodegeneration, and autoimmune disorders.

Functionally, these knockout cell lines serve as a powerful tool for investigating the mechanistic pathways linked to MAPKAPK2, enabling a clearer understanding of its influence on cellular behavior, such as proliferation, apoptosis, and response to extracellular stimuli. By observing the phenotypic changes that occur in the absence of MAPKAPK2, researchers can uncover critical insights into disease mechanisms and potential therapeutic targets.

The scientific importance of MAPKAPK2 Gene Knockout Cell Lines extends to both basic research and clinical applications. These lines can be utilized in drug development processes, assessing therapeutic efficacy and safety by providing a model to simulate the absence of MAPKAPK2 in a controlled environment. Additionally, they are instrumental in screening for compounds that may restore normal function in conditions where MAPKAPK2 is implicated.

One of the key advantages of our MAPKAPK2 Gene Knockout Cell Lines is the high specificity of the knockout, achieved through advanced CRISPR-Cas9 technology, which minimizes off-target effects commonly associated with earlier genomic editing techniques. Our product also comes with comprehensive validation and characterization data, ensuring researchers can trust the reliability and reproducibility of their results.

The unique insights gained from using these cell lines offer tremendous value to researchers and clinicians aiming to better understand the pathology of diseases associated with MAPKAPK2 dysfunction. Our company's expertise in genetic engineering and commitment to providing high-quality biological products make us a reliable partner in advancing your research goals. With our MAPKAPK2 Gene Knockout Cell Lines, you can drive your studies forward with confidence and clarity.

Please note that all services are for research use only. Not intended for any clinical use.

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