Gene: MAFK
Official Full Name: MAF bZIP transcription factor Kprovided by HGNC
Gene Summary: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01957 | MAFK Knockout cell line (HeLa) | Human | MAFK | 1:3~1:6 | Negative | Online Inquiry |
KO01958 | MAFK Knockout cell line (HCT 116) | Human | MAFK | 1:2~1:4 | Negative | Online Inquiry |
KO01959 | MAFK Knockout cell line (HEK293) | Human | MAFK | 1:3~1:6 | Negative | Online Inquiry |
KO01960 | MAFK Knockout cell line (A549) | Human | MAFK | 1:3~1:4 | Negative | Online Inquiry |
MAFK Gene Knockout Cell Lines represent an advanced tool in genetic research and therapeutic development, providing researchers with a functional model to study the role of the MAFK gene in cellular processes. These cell lines are specifically engineered to have the MAFK gene disrupted, allowing for the investigation of how its absence influences various biological pathways, including cellular response to stress and immune system modulation.
The primary mechanism behind the functionality of MAFK Gene Knockout Cell Lines lies in the precise genome editing techniques employed during their development, such as CRISPR-Cas9 or RNA interference. By knocking out the MAFK gene, these cell lines allow for the observation of phenotypic effects that can elucidate the gene's involvement in critical processes, including transcriptional regulation and differentiation. This gives researchers invaluable insights into the pathophysiology of diseases related to MAFK, including various cancers and metabolic disorders.
The scientific importance of these cell lines cannot be overstated. They serve as essential models in both basic and applied research settings, including drug discovery, pathway analysis, and functional genomics. They enable researchers to explore gene function, identify potential drug targets, and assess the impacts of gene interactions in controlled environments.
Compared to traditional methods of gene silencing, such as siRNA or shRNA technologies, MAFK Gene Knockout Cell Lines offer more stable and reproducible outcomes, as the gene is permanently disrupted at the genomic level. This permanence facilitates long-term studies and the integration of knockout traits into subsequent experiments, enhancing experimental rigor and reliability.
Researchers and clinicians particularly value MAFK Gene Knockout Cell Lines for their versatility and effectiveness in translating genetic research into clinically relevant applications. They can help bridge the gap between laboratory findings and real-world therapeutic interventions, thereby advancing the development of novel treatments.
Our expertise in genetic engineering and commitment to scientific innovation make us a leading provider of MAFK Gene Knockout Cell Lines. We focus on delivering high-quality, reproducible tools to facilitate groundbreaking research and expedite advancements in personalized medicine. By choosing our products, researchers can be assured of the sophistication and utility essential for cutting-edge studies.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.