Gene: KLK6
Official Full Name: kallikrein related peptidase 6provided by HGNC
Gene Summary: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35871 | KLK6 Knockout cell line (HCT 116) | Human | KLK6 | 1:2~1:4 | Negative | Online Inquiry |
KLK6 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to provide researchers with a tool for studying the biological functions of the KLK6 gene, which encodes kallikrein-related peptidase 6. The KLK6 protein is implicated in several physiological and pathological processes, including cancer progression, inflammation, and tissue remodeling. By knocking out the expression of this gene, these cell lines facilitate investigations into the role of KLK6 in various cellular pathways, thereby shedding light on its potential impacts in both health and disease.
The key mechanism of action involves the targeted disruption of the KLK6 gene using CRISPR/Cas9 technology, ensuring a high level of specificity and efficiency. This approach allows researchers to observe the phenotypic and functional changes that occur in the absence of KLK6, offering insights into signaling pathways, gene interactions, and cellular responses. Such a model is invaluable in both basic and translational research, as it provides a clearer understanding of the gene's contributions to complex cellular behaviors.
In clinical research settings, KLK6 Gene Knockout Cell Lines serve as a platform for drug discovery and development, enabling the screening of therapeutic compounds that may inhibit KLK6 activity. The investigation of KLK6’s involvement in cancer and other diseases makes these cell lines critical for elucidating disease mechanisms and identifying potential biomarkers.
The primary advantages of our KLK6 Gene Knockout Cell Lines include their precise genetic modification, reproducibility, and ease of use. Unlike traditional knockout models, which may involve cumbersome breeding and lengthy timelines, our cell lines provide immediate access to KLK6-deficient cellular systems, significantly accelerating research timelines.
For researchers and clinicians, investing in KLK6 Gene Knockout Cell Lines opens doors to new avenues of inquiry, enhancing the overall understanding of KLK6 and its role in various diseases. This product represents a cutting-edge resource in genetic research and therapeutic development.
Our company, with its commitment to innovation and excellence in biotechnology, specializes in providing high-quality cell lines and molecular tools tailored to meet the evolving needs of the scientific community. Through rigorous validation and development processes, we ensure that our products support the highest standards of research integrity and reliability.
Please note that all services are for research use only. Not intended for any clinical use.
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