Gene: IPO5
Official Full Name: importin 5provided by HGNC
Gene Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36893 | IPO5 Knockout cell line (HeLa) | Human | IPO5 | 1:3~1:6 | Negative | Online Inquiry |
KO36894 | IPO5 Knockout cell line (HCT 116) | Human | IPO5 | 1:2~1:4 | Negative | Online Inquiry |
KO36895 | IPO5 Knockout cell line (HEK293) | Human | IPO5 | 1:3~1:6 | Negative | Online Inquiry |
KO36896 | IPO5 Knockout cell line (A549) | Human | IPO5 | 1:3~1:4 | Negative | Online Inquiry |
IPO5 Gene Knockout Cell Lines are specialized cellular models that have been engineered to specifically lack the expression of the IPO5 gene, which encodes for Importin 5, a critical protein involved in nuclear transport processes. These knockout cell lines serve as valuable tools for researchers aiming to elucidate the functional role of IPO5 in various cellular contexts, including gene expression regulation, cellular signaling pathways, and the pathophysiology of diseases.
The primary mechanism of action in IPO5 knockout cell lines revolves around the disruption of nucleocytoplasmic transport, particularly influencing the import of specific cargo proteins into the nucleus. By studying cells devoid of IPO5, researchers can investigate how the absence of this import pathway affects cell cycle dynamics, differentiation, and responses to stressors or treatments. Furthermore, these models are instrumental in dissecting the implications of altered nuclear transport in cancer biology and other therapeutic areas.
The scientific significance of IPO5 Gene Knockout Cell Lines extends into both basic and applied research. In clinical settings, these cell lines can be used to explore novel therapeutic strategies targeting nuclear transport mechanisms, potentially leading to breakthroughs in cancer treatment or regenerative medicine. Their availability allows for more reproducible and controlled experiments, ultimately contributing to more reliable data on the interactions between nuclear transport and disease.
Unlike other gene knockout models, our IPO5 Cell Lines are rigorously validated for specificity and efficiency, ensuring that researchers can rely on consistent results. Advanced genome-editing technologies, such as CRISPR/Cas9, were utilized in their development, offering precision that outmatches traditional methods. Additionally, our product comes with comprehensive technical support and documentation to aid researchers in experimental design and data interpretation.
By choosing IPO5 Gene Knockout Cell Lines, researchers and clinicians gain access to an innovative tool that not only enhances their experimental capabilities but also empowers them to advance understanding in critical biological domains. Our company prides itself on its commitment to quality and innovation in biological research tools, backed by a team of experts ready to support your research objectives.
Please note that all services are for research use only. Not intended for any clinical use.
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