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HSF1 Knockout Cell Lines

Gene: HSF1

Official Full Name: heat shock transcription factor 1provided by HGNC

Gene Summary: The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03651 HSF1 Knockout cell line (HeLa) Human HSF1 1:3~1:6 Negative Online Inquiry
KO03652 HSF1 Knockout cell line (HCT 116) Human HSF1 1:2~1:4 Negative Online Inquiry
KO03653 HSF1 Knockout cell line (HEK293) Human HSF1 1:3~1:6 Negative Online Inquiry

Background

HSF1 Gene Knockout Cell Lines represent a cutting-edge tool for researchers focused on understanding the role of the Heat Shock Factor 1 (HSF1) in cellular stress responses and associated pathologies. This product comprises genetically modified cell lines in which the HSF1 gene has been precisely disrupted, allowing for the study of HSF1's function in maintaining cellular homeostasis under stress conditions such as heat shock, oxidative stress, and other environmental challenges.

These cell lines are engineered using CRISPR/Cas9 technology, which facilitates specific gene editing, ensuring high efficiency and reproducibility. When HSF1 is knocked out, the cells display altered expression of heat shock proteins and other crucial stress response elements, thus providing unique insights into the cellular mechanisms that underpin temperature regulation, protein misfolding disorders, and cancer biology.

The scientific importance of HSF1 Gene Knockout Cell Lines cannot be overstated, as they serve as invaluable models for research into neurodegenerative diseases, metabolic syndromes, and aging. By elucidating the pathways involved in stress response modulation, researchers can innovate new therapeutic interventions targeting HSF1 and its downstream effects.

One significant advantage of our HSF1 Gene Knockout Cell Lines lies in their ready-to-use nature, tailored for ease of adoption in a variety of experimental contexts, compared to traditional knockout methods that can be time-consuming and less precise. Furthermore, our cell lines undergo rigorous quality control and validation, ensuring reliability in experimental outcomes.

For researchers and clinicians aiming to delve into the complexities of stress response mechanisms and their implications in disease states, the HSF1 Gene Knockout Cell Lines offer an essential insight-filled resource. As a company dedicated to providing high-quality biological products, we pride ourselves on our expertise and commitment to advancing scientific research through innovative solutions tailored to our customers' needs.

Please note that all services are for research use only. Not intended for any clinical use.

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