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HBEGF Knockout Cell Lines

Gene: HBEGF

Official Full Name: heparin binding EGF like growth factorprovided by HGNC

Gene Summary: Enables growth factor activity; heparin binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of wound healing. Located in cell surface. Is active in extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05970 HBEGF Knockout cell line (HeLa) Human HBEGF 1:3~1:6 Negative Online Inquiry
KO05971 HBEGF Knockout cell line (HCT 116) Human HBEGF 1:2~1:4 Negative Online Inquiry
KO05972 HBEGF Knockout cell line (HEK293) Human HBEGF 1:3~1:6 Negative Online Inquiry
KO05973 HBEGF Knockout cell line (A549) Human HBEGF 1:3~1:4 Negative Online Inquiry

Background

HBEGF Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the heparin-binding epidermal growth factor (HBEGF) gene. These knockout cell lines offer a unique tool for studying the functional role of HBEGF in various biological processes, including cell proliferation, differentiation, and response to external stimuli. The mechanism of action relies on the application of targeted CRISPR-Cas9 gene-editing technology, which introduces precise mutations within the HBEGF gene, leading to a complete loss of its protein product.

In scientific research, these cell lines are invaluable for elucidating the implications of HBEGF in various diseases, such as cancer, where its overexpression has been linked to tumor progression and metastasis. Additionally, they facilitate the exploration of HBEGF’s role in physiological processes like wound healing and tissue regeneration, thereby contributing to advances in regenerative medicine and therapeutic interventions.

Compared to traditional cell lines, HBEGF Gene Knockout Cell Lines provide researchers with a clear advantage in specificity and reliability, allowing for robust and reproducible experimental outcomes. They eliminate the confounding effects of HBEGF, enabling targeted investigations that reveal its true influence on cellular behaviors.

For researchers and clinicians alike, these knockout cell lines enhance experimental design and accuracy, paving the way for groundbreaking discoveries. They also serve as a critical proving ground for the development of HBEGF-targeted therapies. With our deep expertise in genetic engineering and commitment to providing high-quality biological products, we stand ready to support your research endeavors with these innovative cell lines, ensuring that you have the tools necessary to advance science and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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