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GTF2IRD1 Knockout Cell Lines

Gene: GTF2IRD1

Official Full Name: GTF2I repeat domain containing 1provided by HGNC

Gene Summary: The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07499 GTF2IRD1 Knockout cell line (HeLa) Human GTF2IRD1 1:3~1:6 Negative Online Inquiry
KO07500 GTF2IRD1 Knockout cell line (HCT 116) Human GTF2IRD1 1:2~1:4 Negative Online Inquiry
KO07501 GTF2IRD1 Knockout cell line (HEK293) Human GTF2IRD1 1:3~1:6 Negative Online Inquiry
KO07502 GTF2IRD1 Knockout cell line (A549) Human GTF2IRD1 1:3~1:4 Negative Online Inquiry

Background

GTF2IRD1 Gene Knockout Cell Lines are specialized cellular models where the GTF2IRD1 gene has been deliberately disrupted using advanced gene editing techniques. This product provides researchers with the necessary tools to study the functional consequences of GTF2IRD1 loss, a gene implicated in various conditions, particularly the Williams-Beuren syndrome, which is characterized by distinct cognitive and physical traits.

The key mechanism behind these cell lines involves the utilization of CRISPR-Cas9 technology for precise genomic alterations, ensuring the absence of GTF2IRD1 gene expression. This allows scientists to investigate the downstream effects on cellular pathways, gene expression profiles, and associated phenotypic traits. Such analyses are crucial not only for understanding the biology of diseases linked to GTF2IRD1 but also for exploring potential therapeutic avenues.

In research and clinical settings, GTF2IRD1 Gene Knockout Cell Lines offer significant value. They empower scientists to delve into the gene’s role in neurodevelopmental processes, contributing to a more profound understanding of genetic disorders. Their utility extends to drug testing, where modified cellular responses can be assessed, paving the way for targeted therapies. Furthermore, the rapid adaptability of these cell lines allows them to meet the evolving demands of modern research.

What sets our GTF2IRD1 Knockout Cell Lines apart from alternatives is their high efficiency, reproducibility, and the comprehensive validation of the knockout resulting in consistent performance across various studies. As a leading innovator in biological products, our company commits to providing top-tier cell lines that enhance research capabilities and foster advancements in genomic studies. By choosing our knockout cell lines, researchers can rely on quality, precision, and unparalleled support, ensuring the best outcomes in their investigative pursuits.

Please note that all services are for research use only. Not intended for any clinical use.

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