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GMPR2 Knockout Cell Lines

Gene: GMPR2

Official Full Name: guanosine monophosphate reductase 2provided by HGNC

Gene Summary: This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22727 GMPR2 Knockout cell line (HeLa) Human GMPR2 1:3~1:6 Negative Online Inquiry
KO22728 GMPR2 Knockout cell line (HCT 116) Human GMPR2 1:2~1:4 Negative Online Inquiry
KO22729 GMPR2 Knockout cell line (HEK293) Human GMPR2 1:3~1:6 Negative Online Inquiry
KO22730 GMPR2 Knockout cell line (A549) Human GMPR2 1:3~1:4 Negative Online Inquiry

Background

GMPR2 Gene Knockout Cell Lines are genetically engineered cell models designed specifically to disrupt the GMPR2 gene, which encodes for guanosine monophosphate reductase 2, an enzyme involved in nucleotide metabolism and cellular homeostasis. This product offers a remarkable tool for researchers investigating the role of GMPR2 in various biological processes, including cellular proliferation, apoptosis, and metabolic regulation.

The mechanism of action of GMPR2 knockout entails the selective inactivation of the GMPR2 gene, leading to a deficiency in its enzymatic activity. Consequently, this affects nucleotide synthesis pathways, allowing researchers to study the resultant phenotypic changes at the molecular, cellular, and tissue levels. Such investigations are crucial for understanding pathological conditions such as cancer, neurodegenerative diseases, and metabolic disorders, thereby advancing our knowledge in both fundamental and applied biological sciences.

The scientific importance of GMPR2 Gene Knockout Cell Lines extends into both research and clinical applications. In research settings, these cell lines are invaluable for exploring the consequences of GMPR2 toxicity and potential therapeutic targets. Clinicians can leverage these models for preclinical studies aimed at identifying novel treatment strategies that could arise from manipulating nucleotide metabolism.

Compared to alternative products, GMPR2 Gene Knockout Cell Lines are uniquely engineered for specificity and reliability, ensuring high fidelity in experimental outcomes. Our rigorous testing protocols guarantee consistent performance across various experimental platforms, making them a dependable choice for researchers aiming to generate reproducible data.

This product not only enhances the efficiency and accuracy of biological research but also accelerates the translation of basic findings into clinical applications. Researchers and clinicians alike will find the GMPR2 Gene Knockout Cell Lines essential for pushing the boundaries of our understanding of nucleotide metabolism and its implications in health and disease.

With a commitment to scientific excellence, our company specializes in advanced genetic tools and cell line models, ensuring that our products meet the highest standards of quality and reliability for comprehensive biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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