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FOXA1 Knockout Cell Lines

Gene: FOXA1

Official Full Name: forkhead box A1provided by HGNC

Gene Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04712 FOXA1 Knockout cell line (HeLa) Human FOXA1 1:3~1:6 Negative Online Inquiry
KO04713 FOXA1 Knockout cell line (HCT 116) Human FOXA1 1:2~1:4 Negative Online Inquiry
KO04714 FOXA1 Knockout cell line (HEK293) Human FOXA1 1:3~1:6 Negative Online Inquiry
KO04715 FOXA1 Knockout cell line (A549) Human FOXA1 1:3~1:4 Negative Online Inquiry

Background

FOXA1 Gene Knockout Cell Lines are sophisticated biological tools designed to enable researchers to study the functional role of the FOXA1 gene in various cellular processes. FOXA1 (Forkhead Box A1) is a transcription factor integral to numerous biological functions, including development, metabolism, and oncogenesis. Through targeted gene editing techniques like CRISPR/Cas9, these knockout cell lines lack functional FOXA1, facilitating the examination of its regulatory effects on gene expression and cellular behavior.

The key function of FOXA1 Gene Knockout Cell Lines is to serve as a model for elucidating the pathways and networks in which FOXA1 operates. Without FOXA1, researchers can observe alterations in cellular morphology, growth patterns, and signaling pathways linked to critical diseases such as breast cancer and prostate cancer, where FOXA1 has been implicated. The ability to manipulate and analyze these cells allows for a greater understanding of FOXA1's involvement in gene regulation and the underlying molecular mechanisms of diseases.

Scientifically, these cell lines are invaluable assets in both basic research and clinical settings. They contribute to drug discovery efforts by assisting in the identification of novel therapeutic targets and understanding resistance mechanisms in oncology. Their robust application makes them pivotal in unraveling the complexities of gene interactions and signaling pathways.

FOXA1 Gene Knockout Cell Lines offer several advantages over traditional approaches. Unlike transient knockdown methods that can produce variable results, these knockout lines provide a stable genetic modification, ensuring reproducible and reliable results. Furthermore, they can be utilized across various research platforms, including high-throughput screening assays and functional genomics.

For researchers and clinicians seeking to advance their understanding of gene function and therapeutic development, FOXA1 Gene Knockout Cell Lines represent a critical advancement in biological research. Their ability to model disease states where FOXA1 plays a key role aligns with the pressing need for targeted therapies in oncology.

Our company specializes in providing high-quality biological products tailored for cutting-edge research. With a commitment to innovation and scientific excellence, we ensure that our offerings, such as FOXA1 Gene Knockout Cell Lines, empower the scientific community in their pursuit of knowledge and breakthroughs in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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