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EREG Knockout Cell Lines

Gene: EREG

Official Full Name: epiregulinprovided by HGNC

Gene Summary: This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00881 EREG Knockout cell line(U-87 MG) Human EREG 1:3~1:4 Negative Online Inquiry
KO10808 EREG Knockout cell line (HeLa) Human EREG 1:3~1:6 Negative Online Inquiry
KO10809 EREG Knockout cell line (HCT 116) Human EREG 1:2~1:4 Negative Online Inquiry
KO10810 EREG Knockout cell line (A549) Human EREG 1:3~1:4 Negative Online Inquiry

Background

EREG Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to facilitate the study of the epiregulin (EREG) gene’s role in cellular processes and disease mechanisms. These cell lines are created through precise gene editing techniques, allowing researchers to observe the effects of EREG knockout on various biological pathways, including those related to cell proliferation, differentiation, and response to growth factors.

The primary function of EREG gene knockout cell lines is to elucidate the biological and pathological significance of EREG in normal physiology and malignant conditions such as cancer. By eliminating EREG expression, these cell lines enable researchers to investigate the compensatory mechanisms and alternative pathways that might be activated in response to EREG absence. This leads to a deeper understanding of the molecular roles of EREG, particularly its involvement in tumorigenesis, inflammation, and tissue repair processes.

Scientifically, the importance of EREG gene knockout cell lines extends to multiple research and clinical applications, including drug development, biomarker identification, and elucidating the molecular underpinnings of various diseases. These models serve as a critical tool for testing therapeutic approaches targeting EREG and its downstream signaling pathways, potentiallyleading to new interventions in cancers and other diseases characterized by aberrant EREG activity.

Compared to other gene knockout models, our EREG gene knockout cell lines are distinguished by their high editing efficiency and stability, reducing experimental variability. Additionally, they are compatible with a range of assays, including proliferation, migration, and invasion tests, providing a versatile platform for researchers.

For researchers and clinicians engaged in translational research, EREG gene knockout cell lines represent a valuable asset to investigate the nuances of cellular signaling and therapeutic responses. Their use can significantly accelerate the understanding of disease mechanisms, paving the way for novel treatment strategies.

With a commitment to advancing biological research, our company brings expert knowledge and exceptional product offerings to the scientific community, ensuring that researchers have access to reliable tools that enhance their investigative capabilities.

Please note that all services are for research use only. Not intended for any clinical use.

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