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DHRS12 Knockout Cell Lines

Gene: DHRS12

Official Full Name: dehydrogenase/reductase 12provided by HGNC

Gene Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18299 DHRS12 Knockout cell line (HeLa) Human DHRS12 1:3~1:6 Negative Online Inquiry
KO18300 DHRS12 Knockout cell line (HCT 116) Human DHRS12 1:2~1:4 Negative Online Inquiry
KO18301 DHRS12 Knockout cell line (HEK293) Human DHRS12 1:3~1:6 Negative Online Inquiry
KO18302 DHRS12 Knockout cell line (A549) Human DHRS12 1:3~1:4 Negative Online Inquiry

Background

DHRS12 Gene Knockout Cell Lines represent a cutting-edge tool for studying the biological functions of the DHRS12 gene, known for its role in various metabolic pathways and physiological processes. These cell lines are engineered to specifically disrupt the DHRS12 gene, allowing researchers to investigate the gene's function through loss-of-function studies. By knocking out DHRS12, scientists can elucidate its contributions to important cellular mechanisms, including steroid metabolism, redox balance, and lipid biosynthesis.

The primary mechanism behind these knockout cell lines involves CRISPR-Cas9 technology, which enables precise editing of the genome to create a stable, homozygous knockout. This ensures that all cells in the line lack functional DHRS12, providing a consistent model for experimentation. Researchers can utilize these cell lines in various experimental designs, including drug screening, metabolic assessments, and signaling pathway analyses, facilitating a deeper understanding of disease states related to DHRS12 dysregulation.

Scientifically, the DHRS12 Gene Knockout Cell Lines are valuable for applications in both research and clinical settings. They support investigations into metabolic disorders, cancers, and age-related diseases, where DHRS12 may play a significant role. This product is particularly advantageous because it provides a reliable and reproducible model that can lead to new therapeutic targets and insights, overcoming the limitations of primary cell cultures or transient knockdown methods that often lack stability and consistency.

What sets our DHRS12 Gene Knockout Cell Lines apart from alternatives is the rigorous validation process we employ, ensuring the knockout efficiency and specificity of our cell lines. Furthermore, they come with comprehensive user support and documentation to facilitate seamless integration into ongoing research workflows.

By providing researchers and clinicians with high-quality, ready-to-use knockout models, we enable them to advance their studies and discover new pathways to therapeutic intervention. Our expertise in genetic engineering and cell biology ensures that you are equipped with the most innovative tools, driving forward the frontiers of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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