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DENND6B Knockout Cell Lines

Gene: DENND6B

Official Full Name: DENN domain containing 6Bprovided by HGNC

Gene Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol. Predicted to be active in recycling endosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18317 DENND6B Knockout cell line (HeLa) Human DENND6B 1:3~1:6 Negative Online Inquiry
KO18318 DENND6B Knockout cell line (HCT 116) Human DENND6B 1:2~1:4 Negative Online Inquiry
KO18319 DENND6B Knockout cell line (HEK293) Human DENND6B 1:3~1:6 Negative Online Inquiry

Background

DENND6B Gene Knockout Cell Lines are specialized cellular models generated through advanced gene editing techniques, specifically CRISPR/Cas9 technology, to facilitate the functional study of the DENND6B gene in various biological contexts. The DENND6B gene is primarily involved in the regulation of endosome-to-plasma membrane trafficking, impacting various cellular processes, including vesicle formation and intracellular signaling. By creating knockout models, researchers can elucidate the gene's specific roles and contributions to cellular functions, thereby gaining insights into stem cell biology, cancer progression, and neurobiology.

The key function of DENND6B Gene Knockout Cell Lines lies in their ability to enable the dissection of molecular pathways activated by DENND6B. The absence of this gene allows researchers to observe the resultant phenotypic changes at the cellular level, revealing insights into mechanisms like protein trafficking and cellular communication. This provides a robust platform for gene function studies, drug discovery, and the examination of disease mechanisms associated with DENND6B dysregulation.

From a scientific perspective, these knockout cell lines have significant applications in both research and clinical settings. Researchers can utilize them to investigate the genetic basis of diseases and screen for potential therapeutic targets, while clinicians can explore how modulation of DENND6B expression might alter disease outcomes and treatment strategies. The ability to specifically knock out genes gives these models an advantage over traditional methods, which may not fully recapitulate gene function perturbations.

In comparison to alternative products, DENND6B Gene Knockout Cell Lines offer distinct advantages, including precise genetic modification via CRISPR, high throughput compatibility, and the potential for stable integration, allowing for prolonged studies. These attributes enhance reproducibility and reliability in experimental results, which are crucial in scientific research.

The value of this product extends beyond mere functionality; it empowers researchers and clinicians to advance our understanding of complex biological systems and develop innovative treatment approaches. By choosing DENND6B Gene Knockout Cell Lines, users are positioned at the forefront of biological research, supported by a company renowned for its expertise in genetic engineering and commitment to high-quality biologically relevant tools.

Please note that all services are for research use only. Not intended for any clinical use.

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