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CRTC2 Knockout Cell Lines

Gene: CRTC2

Official Full Name: CREB regulated transcription coactivator 2provided by HGNC

Gene Summary: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01344 CRTC2 Knockout cell line (HeLa) Human CRTC2 1:3~1:6 Negative Online Inquiry
KO10379 CRTC2 Knockout cell line (HCT 116) Human CRTC2 1:2~1:4 Negative Online Inquiry
KO10380 CRTC2 Knockout cell line (HEK293) Human CRTC2 1:3~1:6 Negative Online Inquiry
KO10381 CRTC2 Knockout cell line (A549) Human CRTC2 1:3~1:4 Negative Online Inquiry

Background

CRTC2 Gene Knockout Cell Lines are specially developed cellular models that have undergone targeted deletion of the CRTC2 gene, which is crucial for the regulation of various metabolic processes, hormonal signaling, and energy homeostasis. These cell lines serve as a powerful tool for researchers seeking to elucidate the specific roles of CRTC2 in diverse physiological and pathological contexts.

The primary function of the CRTC2 gene is to encode a transcriptional coactivator that interacts with various transcription factors to regulate gene expression. By creating knockout models, scientists can investigate the consequences of CRTC2 deficiency on cellular functions such as glucose metabolism, lipid storage, and stress response pathways. This knockout approach allows for the dissection of complex signaling pathways, synergizing with modern molecular techniques to provide a clearer understanding of the gene's role in metabolic disorders, obesity, and type 2 diabetes.

The scientific significance of CRTC2 Gene Knockout Cell Lines extends to both basic research and translational applications. In clinical settings, the availability of these models facilitates drug development and testing by providing insights into potential therapeutic targets for metabolic diseases. Their unique applications align with the growing emphasis on personalized medicine, enabling tailored approaches in treating metabolic dysfunctions.

Compared to alternative systems, CRTC2 Gene Knockout Cell Lines offer superior specificity and a reliable platform for studying the nuanced effects of CRTC2 on metabolic regulation. Unlike conventional cell lines that express CRTC2, these knockout models eliminate confounding factors, yielding clearer results and reducing experimental variability. This precision makes them a preferred choice for cutting-edge research.

Researchers and clinicians aiming to advance their understanding of metabolism and related diseases will find the CRTC2 Gene Knockout Cell Lines to be an invaluable addition to their toolkit. With our commitment to providing high-quality biological products backed by expertise in the field, we ensure that these cell lines not only meet but exceed the standards required for impactful research.

Please note that all services are for research use only. Not intended for any clinical use.

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