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CREB3L1 Knockout Cell Lines

Gene: CREB3L1

Official Full Name: cAMP responsive element binding protein 3 like 1provided by HGNC

Gene Summary: The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10392 CREB3L1 Knockout cell line (HeLa) Human CREB3L1 1:3~1:6 Negative Online Inquiry
KO10393 CREB3L1 Knockout cell line (HEK293) Human CREB3L1 1:3~1:6 Negative Online Inquiry
KO10394 CREB3L1 Knockout cell line (A549) Human CREB3L1 1:3~1:4 Negative Online Inquiry

Background

CREB3L1 Gene Knockout Cell Lines are genetically modified cell lines that have had the CREB3L1 gene effectively disrupted using advanced CRISPR/Cas9 technology. This gene encodes a transcription factor that plays a crucial role in cellular stress responses, particularly in maintaining proteostasis and modulating metabolic processes. By knocking out CREB3L1, researchers can elucidate its specific functions and interactions within various cellular pathways, providing insights into its role in conditions such as cancer, neurodegeneration, and metabolic disorders.

The knockout of the CREB3L1 gene results in altered cellular responses to stress and changes in the expression of downstream targets, thus enabling scholars to investigate the intricacies of cellular adaptations and the implications of disrupted homeostasis. The unique genetic alteration offers a powerful tool for dissecting signaling networks and understanding gene-environment interactions. Not only does this facilitate basic biological research, but it also carries potential applications in drug discovery and therapeutic development, particularly by identifying novel targets for intervention.

Compared to traditional methods of gene knockdown, such as RNA interference, CREB3L1 Gene Knockout Cell Lines provide a permanent and stable alteration, allowing for prolonged studies without the variability that transient transfection methods can introduce. Additionally, these cell lines come from a well-characterized background, ensuring reproducibility and reliability in experimental outcomes.

For researchers and clinicians focused on understanding complex biological systems, these knockout cell lines represent a critical asset, enabling the development of more effective strategies for disease management. Furthermore, the availability of CREB3L1 Gene Knockout Cell Lines underscores our company's commitment to advancing scientific research by providing high-quality biological products that empower discovery. Our expertise in genetic engineering and cell line development positions us as a trusted partner in the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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