Gene: COX4I1
Official Full Name: cytochrome c oxidase subunit 4I1provided by HGNC
Gene Summary: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38472 | COX4I1 Knockout cell line (HeLa) | Human | COX4I1 | 1:3~1:6 | Negative | Online Inquiry |
KO38473 | COX4I1 Knockout cell line (HCT 116) | Human | COX4I1 | 1:2~1:4 | Negative | Online Inquiry |
KO38474 | COX4I1 Knockout cell line (HEK293) | Human | COX4I1 | 1:3~1:6 | Negative | Online Inquiry |
KO38475 | COX4I1 Knockout cell line (A549) | Human | COX4I1 | 1:3~1:4 | Negative | Online Inquiry |
COX4I1 Gene Knockout Cell Lines are sophisticated biological tools derived from human or murine cellular models in which the COX4I1 gene, encoding a key subunit of cytochrome c oxidase, has been effectively disrupted. This gene is pivotal for mitochondrial function, as it plays a crucial role in the electron transport chain, contributing to ATP synthesis and cellular respiration. The knockout of COX4I1 leads to significant alterations in mitochondrial metabolism, allowing researchers to investigate its influence on cellular oxidative capacity and intracellular signaling pathways associated with energy production.
These cell lines serve as invaluable models for exploring the implications of mitochondrial dysregulation in various pathophysiological conditions such as neurodegenerative diseases, cancer, and metabolic disorders. By enabling the study of COX4I1's role, these knockout cell lines can provide meaningful insights into mitochondrial biogenesis, apoptosis, and cellular stress responses, making them essential for both fundamental research and potential therapeutic development.
One distinct advantage of COX4I1 Gene Knockout Cell Lines is their ability to mimic the exact modifications seen in specific diseases, providing a more realistic context for experimentation compared to traditional cell lines. Furthermore, their robust design ensures high reproducibility and reliability of results, giving researchers confidence in their findings. While alternative models may not accurately replicate the complex interactions within mitochondrial biology, these knockout lines offer a targeted approach to dissecting potential therapeutic interventions.
For researchers and clinicians eager to explore mitochondrial function and its broader implications, COX4I1 Gene Knockout Cell Lines represent a unique asset. They are not just tools for experimentation; they facilitate profound scientific discovery crucial for advancing our understanding of mitochondrial-related disorders. With years of experience in developing innovative biological products, our company is committed to providing high-quality cell lines that support cutting-edge research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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