Gene: CHTF18
Official Full Name: chromosome transmission fidelity factor 18provided by HGNC
Gene Summary: This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18690 | CHTF18 Knockout cell line (HeLa) | Human | CHTF18 | 1:3~1:6 | Negative | Online Inquiry |
KO18691 | CHTF18 Knockout cell line (HCT 116) | Human | CHTF18 | 1:2~1:4 | Negative | Online Inquiry |
KO18692 | CHTF18 Knockout cell line (HEK293) | Human | CHTF18 | 1:3~1:6 | Negative | Online Inquiry |
KO18693 | CHTF18 Knockout cell line (A549) | Human | CHTF18 | 1:3~1:4 | Negative | Online Inquiry |
CHTF18 Gene Knockout Cell Lines are innovative biological tools engineered to facilitate the exploration of gene function and related pathways in cellular contexts. These cell lines are created through the CRISPR-Cas9 gene-editing technology, effectively disrupting the CHTF18 gene within the host genome. The knockout of this gene allows researchers to investigate its biological roles, interactions, and the effect of its absence on cellular physiology, including proliferation, differentiation, and response to various treatments.
Functionally, CHTF18 knockout cell lines provide a unique platform for scientists to dissect the molecular mechanisms underlying various diseases. The targeted knockout allows for the assessment of gene function in disease models, enabling the study of CHTF18's role in pathophysiology and its potential as a therapeutic target. Additionally, this product can be employed in high-throughput screening for drug discovery, facilitating the identification of compounds that may modulate the effects of the gene or related pathways.
The scientific importance of CHTF18 knockout cell lines is underscored by their applications in both basic research and translational science. These cell lines are valuable for pharmacological studies, gene therapy development, and the investigation of genetic interactions that could lead to innovative therapeutic strategies. Moreover, they can be pivotal in the assessment of gene functionality in various biological processes such as DNA repair mechanisms and cell cycle regulation.
What sets CHTF18 knockout cell lines apart from other gene knockout models is their specificity and reliability, stemming from the precision of CRISPR technology. Unlike traditional knockout methods, these cell lines minimize off-target effects and ensure consistency across different experimental setups. They are developed for optimal performance, making them a trusted choice for both academic and industrial laboratories.
For researchers and clinicians intrigued by the intricate mechanisms of gene functionality, CHTF18 Gene Knockout Cell Lines are invaluable, enabling the advancement of knowledge in genetics, cell biology, and therapeutic innovation. This offering epitomizes our company’s commitment to providing state-of-the-art biological products, backed by rigorous research and industry expertise.
Please note that all services are for research use only. Not intended for any clinical use.
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