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CEP295 Knockout Cell Lines

Gene: CEP295

Official Full Name: centrosomal protein 295provided by HGNC

Gene Summary: Enables microtubule binding activity. Involved in several processes, including centriole replication; positive regulation of protein acetylation; and regulation of centrosome duplication. Located in cytosol; microtubule cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24199 CEP295 Knockout cell line (HeLa) Human CEP295 1:3~1:6 Negative Online Inquiry
KO24200 CEP295 Knockout cell line (HCT 116) Human CEP295 1:2~1:4 Negative Online Inquiry
KO24201 CEP295 Knockout cell line (HEK293) Human CEP295 1:3~1:6 Negative Online Inquiry
KO24202 CEP295 Knockout cell line (A549) Human CEP295 1:3~1:4 Negative Online Inquiry

Background

CEP295 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of the CEP295 gene, known for its critical role in ciliary structure and function. The knockout mechanism employed in these cell lines entails the precise deletion of the CEP295 gene using advanced CRISPR-Cas9 technology, providing a powerful tool for researchers to investigate the biological processes influenced by this gene, particularly in relation to ciliary defects and associated diseases.

These cell lines function by enabling the observation of phenotypic changes when the CEP295 gene is inactive. By comparing knockout models to wild-type controls, researchers can elucidate the gene’s role in cellular pathways and disease mechanisms. This is particularly relevant in the context of diseases like ciliopathies, which are often associated with defects in ciliary function leading to diverse pathological conditions.

The scientific importance of CEP295 Gene Knockout Cell Lines cannot be overstated, as they empower researchers to explore gene function, validate therapeutic targets, and accelerate drug discovery processes in areas such as regenerative medicine and developmental biology. In clinical settings, these models can aid in identifying potential biomarkers for patient stratification and personalized treatment approaches in ciliary-related disorders.

What sets our CEP295 Gene Knockout Cell Lines apart from alternative models is their reliability and reproducibility, coupled with a user-friendly protocol for breeding and maintaining the cell lines. Unlike non-specific knockout methods that may generate off-target effects, our CRISPR-edited lines ensure high specificity and efficiency in gene editing, significantly enhancing the accuracy of experimental results.

Researchers and clinicians will find exceptional value in these cell lines, not only for their applications in fundamental biology but also for their translational potential into clinical practice. Leveraging our profound expertise in gene editing technologies, we are committed to providing high-quality biological products that enable groundbreaking discoveries and advance the forefront of scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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