Gene: CCNF
Official Full Name: cyclin Fprovided by HGNC
Gene Summary: This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38651 | CCNF Knockout cell line (HeLa) | Human | CCNF | 1:3~1:6 | Negative | Online Inquiry |
KO38652 | CCNF Knockout cell line (HCT 116) | Human | CCNF | 1:2~1:4 | Negative | Online Inquiry |
KO38653 | CCNF Knockout cell line (HEK293) | Human | CCNF | 1:3~1:6 | Negative | Online Inquiry |
KO38654 | CCNF Knockout cell line (A549) | Human | CCNF | 1:3~1:4 | Negative | Online Inquiry |
CCNF Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the Cyclin F protein, encoded by the CCNF gene, which plays a crucial role in cell cycle regulation and mitosis. These knockout cell lines are created through advanced CRISPR-Cas9 technology, ensuring precise and effective disruption of the CCNF gene. As a result, researchers can explore the functional implications of Cyclin F deficiency in cellular processes such as proliferation, apoptosis, and the cell cycle.
The key mechanism underlying the utility of CCNF Gene Knockout Cell Lines lies in their ability to mimic specific genetic alterations that are often linked to various pathologies, including cancer. By using these cell lines, scientists can investigate the consequences of CCNF perturbation, enabling a deeper understanding of tumorigenesis and cell cycle aberrations. Additionally, these cell lines can be employed in high-throughput screening assays for potential therapeutic agents or to identify biomolecular interactions that might be impacted by CCNF gene disruption.
The scientific importance of these cell lines extends to their application in both basic and applied research settings, where they can contribute significantly to the development of targeted therapies and the understanding of cancer biology. Compared to conventional cell lines that express the CCNF gene, the CCNF Gene Knockout Cell Lines offer researchers a unique opportunity to study the cellular phenotype associated with gene loss, an aspect often overlooked in traditional studies.
This product stands out from alternatives by providing a well-characterized, reproducible model that accurately reflects human biology, thus increasing the translational potential of the research. Beyond their scientific value, the CCNF Gene Knockout Cell Lines come with comprehensive support and user-friendly protocols that facilitate seamless integration into ongoing research projects.
For researchers and clinicians looking to explore the role of Cyclin F in health and disease, these knockout cell lines represent an invaluable tool that can accelerate discovery and innovation. With a commitment to excellence, our company leverages state-of-the-art technology and deep expertise in genetic engineering to deliver products that empower scientific advancements in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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