Gene: CBX8
Official Full Name: chromobox 8provided by HGNC
Gene Summary: Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06362 | CBX8 Knockout cell line (HeLa) | Human | CBX8 | 1:3~1:6 | Negative | Online Inquiry |
KO06363 | CBX8 Knockout cell line (HCT 116) | Human | CBX8 | 1:2~1:4 | Negative | Online Inquiry |
KO06364 | CBX8 Knockout cell line (HEK293) | Human | CBX8 | 1:3~1:6 | Negative | Online Inquiry |
KO06365 | CBX8 Knockout cell line (A549) | Human | CBX8 | 1:3~1:4 | Negative | Online Inquiry |
CBX8 Gene Knockout Cell Lines represent a cutting-edge advancement in the realm of cellular and molecular biology, specifically designed for the study of gene function and regulatory mechanisms. These cell lines are engineered to have a complete, targeted knockout of the CBX8 gene, which encodes for a chromobox protein that plays a critical role in chromatin dynamics and gene expression regulation. By eliminating the CBX8 gene, researchers can observe downstream effects on cellular processes, enabling a deeper understanding of gene regulatory networks and epigenetics.
The primary function of these knockout cell lines lies in their ability to facilitate experiments aimed at elucidating the role of CBX8 in various biological contexts. The absence of the CBX8 protein affects chromatin structure and transcriptional activity, making these cell lines valuable tools for studying mechanisms of gene silencing, cellular differentiation, and oncogenesis. Through the precise manipulation of this gene, researchers can gain insights into how CBX8 contributes to processes like stem cell maintenance, cellular aging, and cancer progression.
Scientifically, CBX8's significance cannot be overstatedāknockout models have become indispensable in both basic and applied research settings, allowing for the exploration of therapeutic targets and disease pathways. These cell lines also serve as critical platforms for drug discovery, enabling researchers to validate potential compounds by assessing their effects on cells devoid of CBX8 function.
In comparison to alternative models, the CBX8 Gene Knockout Cell Lines offer unique advantages, including enhanced specificity and reproducibility. These cell lines provide researchers with a reliable model to investigate the multifaceted roles of CBX8, ultimately leading to more targeted and effective therapeutic interventions.
For researchers and clinicians focused on genetic regulation, epigenetics, or disease pathology, CBX8 Gene Knockout Cell Lines are invaluable assets. They support high-precision studies that can accelerate our understanding of gene function, paving the way for innovative research outcomes. Our company, with its extensive expertise in genetic engineering and cell line development, is committed to providing high-quality biological products that meet the rigorous standards of the scientific community, ensuring that our customers have the tools necessary for breakthrough discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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