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CARD10 Knockout Cell Lines

Gene: CARD10

Official Full Name: caspase recruitment domain family member 10provided by HGNC

Gene Summary: The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11116 CARD10 Knockout cell line (HeLa) Human CARD10 1:3~1:6 Negative Online Inquiry
KO11117 CARD10 Knockout cell line (HCT 116) Human CARD10 1:2~1:4 Negative Online Inquiry
KO11118 CARD10 Knockout cell line (HEK293) Human CARD10 1:3~1:6 Negative Online Inquiry
KO11119 CARD10 Knockout cell line (A549) Human CARD10 1:3~1:4 Negative Online Inquiry

Background

CARD10 Gene Knockout Cell Lines are genetically engineered cell lines designed to lack the CARD10 gene, which plays a crucial role in various cellular processes, including inflammation and cell signaling. These cell lines serve as a vital tool for researchers studying the molecular underpinnings of immune responses and disease mechanisms, particularly in the context of cancer and autoimmune disorders. By disrupting the CARD10 gene, these cell lines facilitate insights into how loss of function affects downstream signaling pathways, providing a clearer understanding of pathophysiological conditions.

The primary mechanism of the CARD10 gene is its involvement in the NF-kB signaling pathway, a critical regulator of immune responses and cell survival. CARD10 acts as an adaptor protein that connects various signals to activate NF-kB transcription factors, leading to the expression of genes involved in inflammation and immune responses. The knockout of CARD10 allows researchers to observe changes in signaling cascades, cytokin production, and overall cell behavior in response to various stimuli, thus revealing potential therapeutic targets.

The scientific importance of CARD10 Gene Knockout Cell Lines cannot be overstated, as they are instrumental in the development of novel therapeutics and understanding disease biology. In clinical research settings, these cell lines enable the exploration of mechanisms behind diseases like cancer, where CARD10's regulatory roles may alter tumor growth or immune evasion. Furthermore, they provide a model system for drug testing, allowing for the assessment of compounds designed to modulate the NF-kB pathway.

Compared to traditional cell lines, CARD10 Gene Knockout Cell Lines offer precise genetic modifications that enhance reproducibility and specificity in experiments. This specificity allows researchers to focus on CARD10-related processes without the confounding effects of the gene's presence, delivering more reliable data. Additionally, these cell lines are derived from widely used parental cell lines, ensuring compatibility with established protocols and assays.

Researchers, clinicians, and pharmaceutical companies can significantly benefit from utilizing CARD10 Gene Knockout Cell Lines in their investigations, as they offer a clearer pathway to understanding diseases and evaluating therapeutic strategies. Our company specializes in the production of high-quality genetic tools and resources, ensuring that our customers have access to cutting-edge technologies that facilitate groundbreaking research. With our expertise and commitment to innovation, we strive to support the scientific community in advancing knowledge and treatment options for complex diseases.

Please note that all services are for research use only. Not intended for any clinical use.

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