Gene: BAIAP2
Official Full Name: BAR/IMD domain containing adaptor protein 2provided by HGNC
Gene Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04881 | BAIAP2 Knockout cell line (HeLa) | Human | BAIAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO04882 | BAIAP2 Knockout cell line (HCT 116) | Human | BAIAP2 | 1:2~1:4 | Negative | Online Inquiry |
KO04883 | BAIAP2 Knockout cell line (HEK293) | Human | BAIAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO04884 | BAIAP2 Knockout cell line (A549) | Human | BAIAP2 | 1:3~1:4 | Negative | Online Inquiry |
BAIAP2 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the BAIAP2 gene, a critical component involved in various cellular processes, including cell signaling and cytoskeletal organization. By utilizing CRISPR-Cas9 technology, these knockout cell lines effectively silence the BAIAP2 gene, allowing researchers to investigate the gene's function and its role in pathological conditions, such as cancer and neurodegenerative diseases.
The key function of BAIAP2 Gene Knockout Cell Lines lies in their ability to provide a robust model for examining the intracellular pathways influenced by the absence of BAIAP2. Without this gene, researchers can analyze alterations in signaling cascades, leading to a deeper understanding of its contribution to cellular dynamics and potential disease mechanisms. This capability is particularly valuable in identifying molecular targets for therapeutic interventions and in the validation of drug candidates.
In terms of scientific importance, these knockout cell lines can be employed in various research domains, including oncology, immunology, and developmental biology. Their utility in high-throughput screening and functional assays positions them as essential tools in both academic and clinical laboratories aiming to elucidate gene function and develop targeted therapies.
BAIAP2 Gene Knockout Cell Lines offer several advantages over conventional methods, such as RNA interference, which may not achieve complete gene silencing or could elicit off-target effects. The precise and permanent knockout of the BAIAP2 gene ensures researchers achieve more reliable and reproducible results, significantly enhancing the validity of their findings.
For researchers and clinicians focused on gene function analysis and therapeutic development, these knockout cell lines represent a transformative resource that streamlines experimental design while fostering innovation in the field of molecular biology. Our company, recognized for its commitment to advancing genetic research, provides high-quality biological products, ensuring that scientists have access to the best tools available to drive their discoveries forward.
Please note that all services are for research use only. Not intended for any clinical use.
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