Gene: ANXA6
Official Full Name: annexin A6provided by HGNC
Gene Summary: Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00183 | ANXA6 Knockout cell line (HEK293) | Human | ANXA6 | 1:3~1:6 | Negative | Online Inquiry |
KO06386 | ANXA6 Knockout cell line (HeLa) | Human | ANXA6 | 1:3~1:6 | Negative | Online Inquiry |
KO06387 | ANXA6 Knockout cell line (HCT 116) | Human | ANXA6 | 1:2~1:4 | Negative | Online Inquiry |
KO06388 | ANXA6 Knockout cell line (A549) | Human | ANXA6 | 1:3~1:4 | Negative | Online Inquiry |
ANXA6 Gene Knockout Cell Lines are specifically engineered cellular models where the Annexin A6 (ANXA6) gene has been silenced or completely disrupted through targeted genome-editing techniques such as CRISPR-Cas9. This product provides researchers with a vital tool for investigating the role of ANXA6 in various biological processes, including membrane dynamics, cellular signaling, and apoptosis. The knockout of ANXA6 allows for the dissection of its functional implications in pathophysiological contexts, offering insights into conditions such as cancer, cardiovascular diseases, and neurodegeneration.
The key function of these cell lines lies in their ability to facilitate the study of the biological effects of ANXA6 deficiency. With ANXA6 being implicated in calcium homeostasis and cytoskeletal organization, knockout cell lines enable researchers to observe alterations in cellular morphology, migration, and adhesion properties. By analyzing these phenotypic changes, scientists can elucidate the specific roles ANXA6 plays in cellular mechanisms which are essential in both normal physiology and disease states.
In terms of scientific importance, ANXA6 Gene Knockout Cell Lines are invaluable for both fundamental research and applied biomedical studies. They are critical for drug discovery processes, allowing researchers to assess the therapeutic potential of compounds targeting ANXA6-related pathways. Moreover, these models enable the validation of ANXA6 as a biomarker for various diseases, thus potentially leading to new diagnostic and therapeutic strategies.
Compared to traditional wild-type cell lines, ANXA6 knockout lines offer the unique advantage of specificity in studying the gene's contributions to biological outcomes. They surpass non-targeted cell lines by eliminating confounding variables, allowing for clearer interpretations of experimental data. This specificity is crucial for generating robust and reproducible research findings.
Researchers and clinicians can greatly benefit from these knockout cell lines as they provide a pioneering approach to understanding complex biological interactions and disease mechanisms. With the increasing interest in personalized medicine, products like ANXA6 Gene Knockout Cell Lines are essential for developing novel therapies tailored to the unique genetic profiles of patients.
Our company is committed to advancing the field of molecular biology by providing high-quality, fully characterized biological products. With a team of experts dedicated to innovation, we ensure that researchers are equipped with the best tools necessary for groundbreaking discoveries and advancements in health and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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