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ANXA1 Knockout Cell Lines

Gene: ANXA1

Official Full Name: annexin A1provided by HGNC

Gene Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02280 ANXA1 Knockout cell line (HeLa) Human ANXA1 1:3~1:6 Negative Online Inquiry
KO02281 ANXA1 Knockout cell line (HCT 116) Human ANXA1 1:2~1:4 Negative Online Inquiry
KO02282 ANXA1 Knockout cell line (HEK293) Human ANXA1 1:3~1:6 Negative Online Inquiry
KO02283 ANXA1 Knockout cell line (A549) Human ANXA1 1:3~1:4 Negative Online Inquiry

Background

ANXA1 Gene Knockout Cell Lines are specifically engineered cell lines that have had the ANXA1 gene, which encodes the annexin A1 protein, disrupted or deleted. This gene plays a pivotal role in various physiological processes, including inflammation, apoptosis, and cellular signaling. By creating knockout variants, researchers can investigate the specific contributions of annexin A1 in cellular functions and its implications in disease states.

The primary function of ANXA1 involves the regulation of inflammatory responses through its interaction with immune cells, including macrophages and neutrophils. The absence of ANXA1 in these knockout cell lines allows scientists to elucidate the biochemical pathways driven by annexin A1 and how its disruption affects cellular behavior. Researchers can explore its roles in tumorigenesis, tissue repair, and as an anti-inflammatory mediator, thereby gaining insights into potential therapeutic targets.

The scientific importance of ANXA1 Gene Knockout Cell Lines extends to both basic and applied research, particularly in understanding pathological conditions like cancer, autoimmune diseases, and chronic inflammation. In clinical settings, the knowledge gathered from these studies may lead to novel strategies for drug development or biomarker identification, thus bridging the gap between laboratory findings and patient care.

One of the significant advantages of using ANXA1 Gene Knockout Cell Lines is that they provide a precise and reproducible model for studying the gene's effects in a controlled environment, unlike transient gene silencing techniques that may yield inconsistent results. Their stability allows for prolonged experiments, enabling researchers to observe long-term effects and develop a deeper understanding of annexin A1-related pathways.

For researchers, clinicians, and biotechnology companies, ANXA1 Gene Knockout Cell Lines represent a critical tool in advancing the field of molecular biology and therapeutic development. By investing in this product, users gain access to cutting-edge technology that aligns with their goals of elucidating complex biological mechanisms.

Our company, dedicated to providing high-quality biological products, draws on extensive expertise in genetic engineering and cell line development, ensuring that our ANXA1 Gene Knockout Cell Lines meet stringent standards for scientific research. With a commitment to innovation and quality, we empower researchers to achieve groundbreaking discoveries in their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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