Home / AK3 Knockout Cell Lines

AK3 Knockout Cell Lines

Gene: AK3

Official Full Name: adenylate kinase 3provided by HGNC

Gene Summary: The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03062 AK3 Knockout cell line (HeLa) Human AK3 1:3~1:6 Negative Online Inquiry
KO03063 AK3 Knockout cell line (HCT 116) Human AK3 1:2~1:4 Negative Online Inquiry
KO03064 AK3 Knockout cell line (HEK293) Human AK3 1:3~1:6 Negative Online Inquiry
KO03065 AK3 Knockout cell line (A549) Human AK3 1:3~1:4 Negative Online Inquiry

Background

AK3 Gene Knockout Cell Lines are genetically engineered cell lines designed to enable the study of the AK3 gene's role in cellular processes and disease mechanisms. By utilizing CRISPR-Cas9 technology, these cell lines facilitate precise disruption of the AK3 gene, allowing researchers to investigate the resultant phenotypic changes and their implications for metabolism and apoptosis pathways. The knockout mechanism works by introducing targeted mutations, resulting in a frame-shift or premature stop codon that effectively silences the gene's expression, providing a powerful tool for functional genomics.

The scientific importance of AK3 Gene Knockout Cell Lines lies in their applications in research, particularly in understanding cellular metabolism, cancer biology, and potential therapeutic targets. By examining the effects of AK3 gene loss, researchers can uncover insights into pathways involved in nucleotide metabolism and cellular energy homeostasis, which have far-reaching implications in disease states like cancer and other metabolic disorders. This gene's role in ATP production and overall cell viability makes these cell lines especially valuable for drug discovery and validation studies.

Compared to alternatives, such as standard wild-type cell lines or non-targeted gene silencing techniques, AK3 Gene Knockout Cell Lines provide a more robust and reproducible methodology for elucidating gene function. The precision with which these cell lines are generated ensures that the observed biological effects are directly attributable to the AK3 knockout, eliminating variables often encountered with less specific approaches.

Researchers, clinicians, and pharmaceutical developers will find significant value in this product, as it not only streamlines experimental design but also enhances the reliability of data generated in studies focused on core biological questions related to the AK3 gene. As leaders in genetic engineering and cell line development, our company is committed to providing high-quality biological products that empower advancements in cellular and biomedical research, ensuring your findings are built on a foundation of precision and scientific rigor.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.