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ACSM3 Knockout Cell Lines

Gene: ACSM3

Official Full Name: acyl-CoA synthetase medium chain family member 3provided by HGNC

Gene Summary: Enables medium-chain fatty acid-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. Implicated in IgA glomerulonephritis. Biomarker of ulcerative colitis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35524 ACSM3 Knockout cell line (HCT 116) Human ACSM3 1:2~1:4 Negative Online Inquiry
KO35525 ACSM3 Knockout cell line (HEK293) Human ACSM3 1:3~1:6 Negative Online Inquiry
KO35526 ACSM3 Knockout cell line (A549) Human ACSM3 1:3~1:4 Negative Online Inquiry

Background

ACSM3 Gene Knockout Cell Lines are specifically engineered cellular models that provide a platform for the exploration and investigation of the functions of the acyl-CoA synthetase medium-chain 3 (ACSM3) gene. This product involves the targeted disruption of the ACSM3 gene, thereby generating cell lines with a non-functional form of this gene. By utilizing CRISPR/Cas9 technology, these knockout cell lines serve as invaluable tools for elucidating the role of ACSM3 in various metabolic pathways, cellular mechanisms, and disease models.

The key functions of the ACSM3 Gene Knockout Cell Lines lie in their capability to facilitate studies regarding fatty acid metabolism and its subsequent effects on energy homeostasis and lipid accumulation. Researchers can assess the physiological and biochemical changes that occur upon loss of ACSM3 function, allowing for the identification of compensatory metabolic pathways that may be activated. This information is crucial in understanding conditions such as obesity, diabetes, and cardiovascular diseases, where fatty acid metabolism is significantly altered.

In terms of scientific importance, ACSM3 Gene Knockout Cell Lines have broad applications in both basic and translational research. They offer the potential for drug screening assays, enabling researchers to identify therapeutic candidates that target altered metabolic pathways. Furthermore, their use in gene function studies contributes to the overall knowledge of gene regulation and expression, which is essential for understanding the pathophysiology of metabolic disorders.

When compared to traditional cell lines that express the ACSM3 gene, these knockout lines provide a clear advantage by yielding unambiguous results devoid of confounding effects from endogenous gene activity. Researchers benefit from a more controlled experimental environment, leading to more reproducible outcomes and clearer insights into the role of ACSM3.

For researchers and clinicians seeking to advance their understanding of metabolic processes and their implications in human health, ACSM3 Gene Knockout Cell Lines represent a significant value. The rigorous development process and validation of these models ensure reliability and robustness in experimental settings, fostering innovation in metabolic research.

Our company's commitment to high-quality biological products, underscored by our expertise in genetic engineering, positions us as a trusted partner in the advancement of scientific research. Offering precise products like the ACSM3 Gene Knockout Cell Lines empowers scientists to push the boundaries of knowledge in metabolic regulation and disease therapy.

Please note that all services are for research use only. Not intended for any clinical use.

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