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ACSF2 Knockout Cell Lines

Gene: ACSF2

Official Full Name: acyl-CoA synthetase family member 2provided by HGNC

Gene Summary: Enables medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26079 ACSF2 Knockout cell line (HeLa) Human ACSF2 1:3~1:6 Negative Online Inquiry
KO26080 ACSF2 Knockout cell line (HCT 116) Human ACSF2 1:2~1:4 Negative Online Inquiry
KO26081 ACSF2 Knockout cell line (HEK293) Human ACSF2 1:3~1:6 Negative Online Inquiry
KO26082 ACSF2 Knockout cell line (A549) Human ACSF2 1:3~1:4 Negative Online Inquiry

Background

ACSF2 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the function of the ACSF2 gene, a critical player in the biosynthesis of acylcarnitines, which are essential in fatty acid metabolism and energy production. These knockout cell lines are generated using advanced CRISPR-Cas9 technology, ensuring precise gene editing that completely disrupts the ACSF2 gene's function, allowing researchers to elucidate the role of this gene in various physiological and pathological processes.

The key mechanisms of the ACSF2 Gene Knockout Cell Lines involve the complete absence of the ACSF2 protein, leading to alterations in metabolic pathways that highlight its role in mitochondrial function and lipid metabolism. By comparing the metabolic profiles of these knockout cell lines with wild-type counterparts, researchers can gain insights into how loss of ACSF2 affects cellular energy homeostasis, contributes to metabolic disorders, and influences cellular responses to stress.

The scientific importance of utilizing these knockout cell lines is underscored by their application in both fundamental and translational research. They provide valuable models for studying the implications of ACSF2 function in diseases like obesity, diabetes, and cardiomyopathies, facilitating the identification of potential therapeutic targets and biomarkers for these conditions.

One of the distinct advantages of our ACSF2 Gene Knockout Cell Lines is the precision and efficiency of the knockout process, which enables high reproducibility in experimental results. Additionally, these cell lines are readily available and validated for a range of assays, making them an ideal choice for researchers who require high-quality, ready-to-use models for their studies.

Researchers and clinicians will find immense value in these cell lines as they help decode complex metabolic interactions, ultimately paving the way for innovative therapeutic strategies. Our company specializes in providing cutting-edge biological products, leveraging a wealth of experience and expertise to support the evolving needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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