Gene: ACP4
Official Full Name: acid phosphatase 4provided by HGNC
Gene Summary: Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22138 | ACP4 Knockout cell line (HEK293) | Human | ACP4 | 1:3~1:6 | Negative | Online Inquiry |
ACP4 Gene Knockout Cell Lines are specially engineered cellular models that have had the ACP4 gene, which encodes for a key enzyme in the metabolic pathway of collagen degradation, functionally disrupted. This gene knockout allows for the investigation of ACP4's role in cellular processes, particularly those involving collagen homeostasis, tumor biology, and tissue engineering.
The key functions of these cell lines involve enabling researchers to elucidate the biological pathways governed by ACP4. By disrupting the gene, scientists can study the resultant phenotypic changes and their implications, such as alterations in cell proliferation, migration, and response to extracellular matrix signals. This mechanistic understanding can lead to insights into diseases characterized by ECM dysregulation, including certain cancers and fibrotic disorders.
Scientifically, the ACP4 Gene Knockout Cell Lines are crucial for advancing research in multiple areas, particularly in understanding the molecular underpinnings of various pathologies and in developing targeted therapeutic strategies. In clinical settings, these cell lines may facilitate drug screening processes, provide a platform for biomarker discovery, or serve as a valuable resource for regenerative medicine applications.
Compared to traditional cell lines, ACP4 knockout models offer unique advantages, including the precision of gene editing technology that ensures consistent and reproducible results. This specificity provides a robust framework for researchers looking to delve deeper into the nuanced roles of ACP4 without the confounding effects found in wild-type cell lines.
For researchers and clinicians, the ACP4 Gene Knockout Cell Lines represent a significant tool that enables a deeper exploration of cellular mechanics, potential therapeutic avenues, and enhanced understanding of disease mechanisms. Our company has a longstanding expertise in providing high-quality, state-of-the-art biological products, ensuring that researchers have the resources necessary to drive their scientific discoveries forward.
Please note that all services are for research use only. Not intended for any clinical use.
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