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ACOX2 Knockout Cell Lines

Gene: ACOX2

Official Full Name: acyl-CoA oxidase 2provided by HGNC

Gene Summary: The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34258 ACOX2 Knockout cell line (HCT 116) Human ACOX2 1:2~1:4 Negative Online Inquiry
KO34259 ACOX2 Knockout cell line (A549) Human ACOX2 1:3~1:4 Negative Online Inquiry

Background

ACOX2 Gene Knockout Cell Lines are specialized laboratory cell lines in which the acyl-CoA oxidase 2 (ACOX2) gene has been inactivated through targeted genetic engineering techniques, such as CRISPR-Cas9. ACOX2 is critical in the beta-oxidation of fatty acids, playing a vital role in lipid metabolism. By knocking out this gene, these cell lines enable researchers to study the physiological and pathological consequences of disrupted lipid oxidation pathways, providing insights into metabolic disorders, obesity, and other related diseases.

These cell lines function as valuable tools for elucidating the mechanisms by which lipid metabolism influences cellular processes, including energy homeostasis, cell signaling, and apoptosis. Researchers can use ACOX2 knockout lines to investigate the contribution of fatty acid metabolism to cancer, inflammatory responses, and neurodegenerative conditions. The ability to observe the effects of ACOX2 loss in a controlled environment allows for a deeper understanding of the gene's role, which may uncover therapeutic targets for intervention.

The scientific importance of ACOX2 Gene Knockout Cell Lines extends to both research and clinical applications. In academic and industrial research settings, these cell lines facilitate the development of novel treatments for metabolic syndromes, as well as offer a platform for drug screening aimed at modulating lipid metabolism. Compared to traditional approaches, such as pharmacological inhibition, knockout models offer a more precise method of dissecting gene function and the biological pathways involved.

Distinct advantages of ACOX2 knockout cell lines include their reliability and reproducibility. With their defined genetic background, they maintain stable knockout characteristics, allowing for consistent results across multiple experiments. Researchers benefit from the specificity of this tool, which can lead to more accurate data collection and analysis, ultimately driving advancements in the field of metabolic research.

In conclusion, ACOX2 Gene Knockout Cell Lines represent an essential resource for researchers and clinicians focused on elucidating the complex interplay of lipid metabolism in health and disease. Our company is dedicated to providing high-quality biological products and technical support, ensuring that every scientist has access to the cutting-edge tools necessary for advancing their work in metabolic research.

Please note that all services are for research use only. Not intended for any clinical use.

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