NOD2 Knockout cell line (AC16)

Catalog Number: KOA07675

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Specifications

Product Information
Product Name	NOD2 Knockout cell line (AC16)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Fibroblast-like, adherent
Passage ratio	1：3-1：4
species	Human
Gene	NOD2
Gene ID	64127
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90% DMEM/F12+10% FBS
Parental Cell Line	AC16
Quality Control	Genotype: NOD2 Knockout cell line (AC16)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	nucleotide binding oligomerization domain containing 2provided by HGNC
Also known as	CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1
Gene Description	This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Expression	Broad expression in bone marrow (RPKM 3.3), appendix (RPKM 2.5) and 16 other tissues See more

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