Lipopolysaccharide (mucophilic-Akkermania)

Name: Lipopolysaccharide (mucophilic-Akkermania)
Brand: CD Biosynsis
SKU: LPS0023
Availability: InStock

Catalog Number: LPS0023

Specifications Overview Downloads Related products

Specifications

Product Information
Size	5mg
Description	Damages the barrier function of tight junctions in Caco-2 cell monolayers; co-cultures with A. muciniphila to study its effect on NLR expression in Raw264.7 cells containing 3 (NLRP3) of the NLR family pyrin domain; activates HepG2 cells with endotoxin and palmitic acid (PA).
Appearance	Lyophilized powder
Content	Mucophilus-Akkermansia

Properties
Storage Conditions	Store at 2-8℃.
Shipping Conditions	Refrigerated Transport

Overview

Akkermansia muciniphila (A. muciniphila) is a Gram-negative, anaerobic, non-motile, non-spore forming, and oval bacterium. LPS from A. muciniphila stimulates the production of embryonic cell alkaline phosphatase (SEAP) through TLR4 in a NF-κB-dependent manner. Furthermore, it induces IL-8, IL-6, and very little IL-10 and TNF-α in peripheral blood mononuclear cells (PBMC). Stimulation of intestinal cells by A. muciniphila to produce IL-8 has been shown to be significantly lower than that by E. coli (100-fold). The low pro-inflammatory activity maintains the mucosal-associated immune system at appropriate levels to produce mucosal homeostasis.

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Please note that all services are for research use only. Not intended for any clinical use.

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