BMAL1 Knockout cell line (TPC-1)

Catalog Number: KOA63238

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Specifications

Product Information
Product Name	BMAL1 Knockout cell line (TPC-1)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Epithelial-like, adherent
Passage ratio	1:5-1:8
species	Human
Gene	BMAL1
Gene ID	406
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90%DMEM+10%FBS
Parental Cell Line	TPC-1
Quality Control	Genotype: BMAL1 Knockout cell line (TPC-1)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	basic helix-loop-helix ARNT like 1provided by HGNC
Also known as	TIC; JAP3; MOP3; ARNTL; PASD3; ARNTL1; BMAL1c; bHLHe5
Gene Description	The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021]
Expression	Ubiquitous expression in adrenal (RPKM 8.3), skin (RPKM 6.7) and 25 other tissues See more

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