Gene: BMAL1
Official Full Name: basic helix-loop-helix ARNT like 1provided by HGNC
Gene Summary: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04068 | BMAL1 Knockout cell line (HeLa) | Human | BMAL1 | 1:3~1:6 | Negative | Online Inquiry |
KO04069 | BMAL1 Knockout cell line (HCT 116) | Human | BMAL1 | 1:2~1:4 | Negative | Online Inquiry |
KO04070 | BMAL1 Knockout cell line (HEK293) | Human | BMAL1 | 1:3~1:6 | Negative | Online Inquiry |
KO04071 | BMAL1 Knockout cell line (A549) | Human | BMAL1 | 1:3~1:4 | Negative | Online Inquiry |
BMAL1 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the expression of the BMAL1 gene, a critical component of the circadian rhythm regulatory pathway. This product serves as a powerful tool for researchers studying the physiological and molecular roles of circadian rhythms in various biological processes, such as metabolism, neurobiology, and cell proliferation. BMAL1, a transcription factor, partners with CLOCK to activate genes that govern circadian function; therefore, the absence of this gene profoundly impacts cellular behavior and responses.
The key function of these knockout cell lines involves the disruption of circadian rhythm regulation, allowing scientists to explore the downstream effects of this alteration. By studying these cell lines, researchers can investigate the lifespan and health of cells in absence of rhythmic signaling, providing insights into a variety of conditions, including metabolic disorders and mood disorders, linked to circadian dysregulation.
In scientific research and clinical applications, BMAL1 Gene Knockout Cell Lines hold substantial importance. They are instrumental in high-throughput screening assays to identify potential therapeutic targets for circadian-related diseases, thus offering opportunities for novel drug development. Furthermore, these cell lines can be utilized in developing advanced models of human diseases that exhibit altered circadian patterns, enhancing our understanding of their pathophysiology.
One of the standout advantages of our BMAL1 Gene Knockout Cell Lines is their robust validation and reproducibility, ensuring reliable results across experiments. Unlike alternative models that may exhibit poor fidelity to human circadian patterns, our cell lines provide a consistent and accurate foundation for experimental replication. Researchers can trust in the performance and stability of these knockout lines to yield meaningful and interpretable data.
Investing in BMAL1 Gene Knockout Cell Lines is crucial for those dedicated to unraveling the complexities of circadian biology and its clinical implications. By leveraging these specialized cell lines, researchers and clinicians can accelerate discoveries that may lead to improved therapeutic strategies for circadian-related disorders.
Our company is committed to advancing the field of molecular biology through cutting-edge products and expertise. We specialize in providing high-quality genetic models that empower scientists to enhance their research endeavors and achieve transformative results.
Please note that all services are for research use only. Not intended for any clinical use.
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