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WASF2 Knockout Cell Lines

Gene: WASF2

Official Full Name: WASP family member 2provided by HGNC

Gene Summary: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32213 WASF2 Knockout cell line (HeLa) Human WASF2 1:3~1:6 Negative Online Inquiry
KO32214 WASF2 Knockout cell line (HCT 116) Human WASF2 1:2~1:4 Negative Online Inquiry
KO32215 WASF2 Knockout cell line (HEK293) Human WASF2 1:3~1:6 Negative Online Inquiry
KO32216 WASF2 Knockout cell line (A549) Human WASF2 1:3~1:4 Negative Online Inquiry

Background

WASF2 Gene Knockout Cell Lines represent a cutting-edge tool in the field of molecular and cellular biology, specifically designed to investigate the functions of the WASF2 gene and its contributions to cellular processes. These cell lines have been genetically modified to achieve a knockout of the WASF2 gene, which is known to play a crucial role in actin polymerization and cellular motility. By eliminating the expression of this gene, researchers can dissect the implications of WASF2 in cancer metastasis, immune responses, and cellular signaling pathways.

The key function of WASF2 is its involvement in the regulation of the Arp2/3 complex, which is pivotal for the nucleation of actin filaments. The knockout of WASF2 effectively disrupts this pathway, allowing researchers to examine alterations in cell morphology, migration, and invasion capabilities. Such insights are invaluable for understanding diseases where these processes are dysregulated, particularly in tumor biology and immunology.

In both research and clinical settings, WASF2 Gene Knockout Cell Lines serve as a fundamental asset for elucidating the biological mechanisms underpinning various pathologies. They enable the examination of isoform-specific contributions to cellular functions and facilitate drug discovery by providing a platform for screening anti-metastatic agents.

Compared to alternative methods, such as transient knockdown techniques, our knockout cell lines offer a stable and reproducible model for long-term studies, ensuring that experimental results are consistent and reliable. This stability facilitates a deeper understanding of chronically altered cellular behaviors without the variability introduced by transient transfection methods.

For researchers and clinicians alike, the WASF2 Gene Knockout Cell Lines deliver unparalleled value by offering a comprehensive means to explore the complexities of gene function in a controlled environment. Our company is dedicated to providing high-quality biological products that empower discoveries in biomedical research, backed by years of expertise and commitment to scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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