Gene: VCL
Official Full Name: vinculinprovided by HGNC
Gene Summary: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04694 | VCL Knockout cell line (HeLa) | Human | VCL | 1:3~1:6 | Negative | Online Inquiry |
KO04695 | VCL Knockout cell line (HCT 116) | Human | VCL | 1:2~1:4 | Negative | Online Inquiry |
KO04696 | VCL Knockout cell line (HEK293) | Human | VCL | 1:3~1:6 | Negative | Online Inquiry |
KO04697 | VCL Knockout cell line (A549) | Human | VCL | 1:3~1:4 | Negative | Online Inquiry |
VCL Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate the study of the specific role of the Vinculin gene (VCL) in various biological processes. These cell lines are generated using sophisticated gene editing technologies, such as CRISPR-Cas9, which allow for the targeted disruption of the VCL gene, leading to loss-of-function phenotypes. This gene plays critical roles in cell adhesion, mechanotransduction, and actin cytoskeleton organization, making these knockout lines vital for researchers aiming to dissect the molecular pathways involved in cellular dynamics and disease mechanisms.
In terms of function, VCL Gene Knockout Cell Lines provide an invaluable platform for understanding how Vinculin regulates cellular responses to external stimuli, including mechanical stress and biochemical signals. By observing the resultant phenotypic changes, researchers can elucidate the implications of VCL loss in processes such as cancer metastasis, cardiovascular diseases, and tissue development, which are hallmarks of numerous pathologies. Their application spans fundamental research to advanced therapeutic investigations, allowing scientists to explore potential targets for intervention.
One of the product’s distinctive advantages is its highly specific and reproducible gene editing, ensuring that the effects observed are directly attributable to VCL inactivation, thereby minimizing off-target effects. Additionally, by providing reliable and consistent results, these knockout cell lines enhance the reproducibility of experimental outcomes, a critical consideration for both academic and clinical research environments.
For researchers and clinicians, the VCL Gene Knockout Cell Lines represent a powerful resource that not only accelerates experimentation but also contributes valuable insights into cellular behavior and pathophysiology. Their utilization can lead to significant discoveries, fostering innovation in both basic and translational science.
Our company is committed to providing high-quality biological products that meet the stringent demands of contemporary research. With our expertise in gene editing technologies and a focus on customer satisfaction, we are dedicated to supporting the scientific community in unlocking the complexities of gene function and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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