Gene: STRN
Official Full Name: striatinprovided by HGNC
Gene Summary: Enables armadillo repeat domain binding activity; nuclear estrogen receptor binding activity; and protein phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13655 | STRN Knockout cell line (HeLa) | Human | STRN | 1:3~1:6 | Negative | Online Inquiry |
KO13656 | STRN Knockout cell line (HCT 116) | Human | STRN | 1:2~1:4 | Negative | Online Inquiry |
KO13657 | STRN Knockout cell line (HEK293) | Human | STRN | 1:3~1:6 | Negative | Online Inquiry |
KO13658 | STRN Knockout cell line (A549) | Human | STRN | 1:3~1:4 | Negative | Online Inquiry |
STRN Gene Knockout Cell Lines are genetically engineered cell lines designed to study the functional implications of the striatin (STRN) gene, which plays a significant role in various cellular processes, including signal transduction and cytoskeletal organization. By systematically disrupting the STRN gene, these cell lines facilitate the examination of its specific roles in cell physiology, disease mechanisms, and developmental biology.
The key function of the STRN gene knockout is to eliminate the expression of the STRN protein, thereby providing a clear model to investigate the consequences of STRN deficiency. Mechanistically, these cell lines can reveal how loss of STRN influences pathways such as Wnt signaling, intracellular calcium dynamics, and cell adhesion, shedding light on its involvement in neurodegenerative diseases and cancer progression.
The scientific importance of STRN Gene Knockout Cell Lines resides in their ability to serve as critical tools for researchers exploring therapeutic targets and biological mechanisms underlying STRN-associated disorders. In clinical research, they can be utilized to evaluate the efficacy of potential treatments, assess drug responses, and explore the interplay of genetic factors in health and disease.
One of the unique advantages of our STRN Gene Knockout Cell Lines is their customization, allowing users to select from various cell types that are most relevant to their specific research focus. In comparison to traditional research methods, these knockout lines offer a more efficient and cost-effective means of validating hypotheses and conducting experiments without the complexity introduced by endogenous STRN expression.
For researchers and clinicians, the value of utilizing STRN Gene Knockout Cell Lines lies in the precision and reliability they offer for studying STRN's role in pathological contexts. Our extensive expertise in cellular model systems ensures that these lines are produced under rigorous quality controls, enhancing their utility and reproducibility in experimental setups.
With our commitment to advancing biological research through innovative products, we are dedicated to supporting the scientific community with high-quality genomic tools that enable groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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